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. 2020 Dec;48(12):300060520980596.
doi: 10.1177/0300060520980596.

Obesity, dyslipidemia, and high blood pressure are associated with cardiovascular risk, determined using high-sensitivity C-reactive protein concentration, in young adults

Luz Elena Ramos-Arellano  1 , Ines Matia-Garcia  1 , Linda Anahi Marino-Ortega  1 , Natividad Castro-Alarcón  1 , José Francisco Muñoz-Valle  2 , Lorenzo Salgado-Goytia  1 , Aralia Berenice Salgado-Bernabé  1 , Isela Parra-Rojas  1
Affiliations

Obesity, dyslipidemia, and high blood pressure are associated with cardiovascular risk, determined using high-sensitivity C-reactive protein concentration, in young adults

Luz Elena Ramos-Arellano et al. J Int Med Res. 2020 Dec.

Abstract

Objective: Few studies have investigated the relationships between high-sensitivity C-reactive protein (hs-CRP) concentration and conventional cardiometabolic markers in young adults. The aim of this study was to characterize the cardiometabolic profile of young adults who are at high cardiovascular risk, according to hs-CRP concentration.

Methods: A cross-sectional study was conducted in 300 young adults (18 to 30 years old) from southern Mexico (n = 150 normal-weight and n = 150 obese). Their circulating lipid and glucose concentrations were measured using colorimetric enzymatic assays, and their hs-CRP, ApoA, and ApoB concentrations were measured using turbidimetric assays.

Results: The most prevalent abnormalities in the participants with high cardiovascular risk, determined using an hs-CRP >28.57 nmol/L, were high waist circumference (85.7%), obesity (83.9%), high low-density lipoprotein-cholesterol (64.3%), low high-density lipoprotein-cholesterol (50%), Apo B in the highest tertile (39.3%), hypertriglyceridemia (35.7%), and high blood pressure (30.4%). In addition, there were strong associations between hs-CRP >28.57 nmol/L and obesity (odds ratio [OR] = 13.9), high waist circumference (OR = 8.0), hypertriglyceridemia (OR = 4.0), high blood pressure (OR = 3.4), hypercholesterolemia (OR = 2.8), and Apo B in the highest tertile (OR = 2.4).

Conclusion: The principal cardiometabolic alterations associated with high cardiovascular risk, determined using hs-CRP, are obesity, dyslipidemia, and high blood pressure in young adults.

Keywords: Cardiometabolic risk; Mexico; dyslipidemia; high blood pressure; high-sensitivity C-reactive protein; obesity; young adult.

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Conflict of interest statement

Declaration of conflicting interest: The authors declare that there is no conflict of interest.

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