Renin-angiotensin system inhibitors and COVID-19: overwhelming evidence against an association

Affiliations

¹ Clinical Pharmacology Unit, University Hospital Príncipe de Asturias, and School of Medicine and Health Sciences, University of Alcalá, Madrid, Spain. Electronic address: francisco.abajo@uah.es.

Comment

Francisco J de Abajo. Lancet Digit Health. 2021 Feb.

. 2021 Feb;3(2):e70-e71.

doi: 10.1016/S2589-7500(20)30294-6. Epub 2020 Dec 17.

¹ Clinical Pharmacology Unit, University Hospital Príncipe de Asturias, and School of Medicine and Health Sciences, University of Alcalá, Madrid, Spain. Electronic address: francisco.abajo@uah.es.

No abstract available

Comment on

Renin-angiotensin system blockers and susceptibility to COVID-19: a multinational open science cohort study.
Morales DR, Conover MM, You SC, Pratt N, Kostka K, Duarte-Salles T, Fernández-Bertolín S, Aragón M, DuVall SL, Lynch K, Falconer T, van Bochove K, Sung C, Matheny ME, Lambert CG, Nyberg F, Alshammari TM, Williams AE, Park RW, Weaver J, Sena AG, Schuemie MJ, Rijnbeek PR, Williams RD, Lane JCE, Prats-Uribe A, Zhang L, Areia C, Krumholz HM, Prieto-Alhambra D, Ryan PB, Hripcsak G, Suchard MA. Morales DR, et al. medRxiv [Preprint]. 2020 Jun 12:2020.06.11.20125849. doi: 10.1101/2020.06.11.20125849. medRxiv. 2020. Update in: Lancet Digit Health. 2021 Feb;3(2):e98-e114. doi: 10.1016/S2589-7500(20)30289-2. PMID: 32587982 Free PMC article. Updated. Preprint.
Renin-angiotensin system blockers and susceptibility to COVID-19: an international, open science, cohort analysis.
Morales DR, Conover MM, You SC, Pratt N, Kostka K, Duarte-Salles T, Fernández-Bertolín S, Aragón M, DuVall SL, Lynch K, Falconer T, van Bochove K, Sung C, Matheny ME, Lambert CG, Nyberg F, Alshammari TM, Williams AE, Park RW, Weaver J, Sena AG, Schuemie MJ, Rijnbeek PR, Williams RD, Lane JCE, Prats-Uribe A, Zhang L, Areia C, Krumholz HM, Prieto-Alhambra D, Ryan PB, Hripcsak G, Suchard MA. Morales DR, et al. Lancet Digit Health. 2021 Feb;3(2):e98-e114. doi: 10.1016/S2589-7500(20)30289-2. Epub 2020 Dec 17. Lancet Digit Health. 2021. PMID: 33342753 Free PMC article.

1. Ferrario CM, Jessup J, Chappell MC. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005;111:2605–2610. - PubMed
1. Zhou F, Yu T, Du R. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan. China: a retrospective cohort study. Lancet. 2020;395:1054–1062. - PMC - PubMed
1. Sommerstein R. Re: preventing a covid-19 pandemic: ACE inhibitors as potential risk factor for fatal Covid-19. BMJ. 2020;368:m810. - PubMed
1. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020;8:e21. - PMC - PubMed
1. Mancia G, Rea F, Ludegnani M, Apolone G, Corrao G. Renin–angiotensin–adosterone system blockers and the risk of Covid-19. N Engl J Med. 2020;382:2431–2440. - PMC - PubMed