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. 2020 Dec;13(4):174-178.
doi: 10.1177/1753495X19852817. Epub 2019 Jun 15.

Renal biopsy findings during and after pregnancy

Frances Conti-Ramsden  1 , Paul Bass  2 , Lucy C Chappell  1 , Kate Bramham  3
Affiliations

Renal biopsy findings during and after pregnancy

Frances Conti-Ramsden et al. Obstet Med. 2020 Dec.

Abstract

Background: Chronic kidney disease is estimated to affect up to 6% of women of reproductive age. Maternity care represents an opportunity for early diagnosis but there is limited understanding of chronic kidney disease aetiology occurring in or revealed by pregnancy.

Methods: A retrospective evaluation of renal biopsies during and after pregnancy between 2000 and 2015 was undertaken. A large academic health centre pathology database was searched for free text pregnancy-related terms, restricted to typology code 71000 (kidney). Indications and findings of postpartum renal biopsies were reviewed.

Results: Sixty-three renal biopsy reports were identified. Of 45 biopsies performed postpartum, 34 (75.6%) investigated persistent postpartum proteinuria. 20/34 (70.6%) of these biopsies yielded a primary renal disease, and 6/34 (17.6%) women had progressed to end stage renal disease at latest follow-up.

Conclusion: Renal biopsy findings of women investigated for persistent postpartum proteinuria revealed a high incidence of histological diagnosis of de novo renal disease.

Keywords: Postpartum; proteinuria; renal biopsy.

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Conflict of interest statement

Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Flow diagram illustrating case selection.
See this image and copyright information in PMC

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