Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 1987 Apr;4(2):86-91.
doi: 10.1023/a:1016402616081.

Kinetic-effect models and their applications

J Grevel  1
Affiliations
Review

Kinetic-effect models and their applications

J Grevel. Pharm Res. 1987 Apr.

Abstract

This article focuses on mathematical models that analyze the time course of drug effects in humans. Any such model, whether parametric or nonparametric, is termed a kinetic-effect model (KEM). These models serve to describe (interpolation) and to predict (extrapolation) the effect-time profile. KEMs are applicable to many problems in pharmaceutics, pharmacology, and clinical pharmacology.

PubMed Disclaimer

References

    1. Clin Pharmacokinet. 1981 Nov-Dec;6(6):429-53 - PubMed
    1. Crit Rev Bioeng. 1981;5(4):273-322 - PubMed
    1. J Cardiovasc Pharmacol. 1986;8 Suppl 6:S16-9 - PubMed
    1. Farmaco Sci. 1968 Oct;23(10):907-18 - PubMed
    1. Clin Pharmacol Ther. 1986 Jul;40(1):86-93 - PubMed

LinkOut - more resources