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Review
. 2020 Dec 2:10:602378.
doi: 10.3389/fonc.2020.602378. eCollection 2020.

The Epigenetics of Glioma Stem Cells: A Brief Overview

Luis M Valor  1 , Irati Hervás-Corpión  1
Affiliations
Review

The Epigenetics of Glioma Stem Cells: A Brief Overview

Luis M Valor et al. Front Oncol. .

Abstract

Glioma stem cells (GSCs) are crucial in the formation, perpetuation and recurrence of glioblastomas (GBs) due to their self-renewal and proliferation properties. Although GSCs share cellular and molecular characteristics with neural stem cells (NSCs), GSCs show unique transcriptional and epigenetic features that may explain their relevant role in GB and may constitute druggable targets for novel therapeutic approaches. In this review, we will summarize the most important findings in GSCs concerning epigenetic-dependent mechanisms.

Keywords: DNA; H3.3; HDACi; Polycomb; acetylation; glioblastoma; histone; methylation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Summary of the epigenetic regulation of the GSC phenotype. (A) Coordinated actions and regulation of Polycomb complexes; (B) role of H3.3 in pediatric and adult GSCs as a result of gain and loss-of-function, respectively; (C) TET3-STAT regulation by the laminin-integrin signaling pathway; (D) H3K23ac-TRIM24-STAT regulation by the EGFRvIII signaling pathway. See main text for further details.
See this image and copyright information in PMC

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