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Review
. 2020 Sep 3;92(8):100-107.
doi: 10.26442/00403660.2020.08.000792.

[The eosinophilic esophagitis and IgG4-related disease involving the esophagus]

[Article in Russian]
N V Bakulina  1 , V I Simanenkov  1 , S L Vorobyev  2 , S V Tikhonov  1 , N B Lishchuk  1 , I G Bakulin  1
Affiliations
Review

[The eosinophilic esophagitis and IgG4-related disease involving the esophagus]

[Article in Russian]
N V Bakulina et al. Ter Arkh. .

Abstract
in English, Russian

The study of eosinophilic esophagitis has become a dynamic field with an evolving understanding of the pathogenesis, diagnosis, and treatment. Immunoglobulin G4 (IgG4)-related disease exhibits systemic involvement but very rarely involves the esophagus. The article presents a clinical case: the history of ulcer and stricture of the esophagus in a young man of 17 years. The patient was finally diagnosed with IgG4-related and eosinophilic esophagitis and showed a good response to corticosteroid therapy. We herein report a rare case of dysphagia associated with IgG4-related disease and eosinophilic. We presented a review of modern data on the relationship of eosinophilic esophagitis and pathological IgG4-response.

Представления об эозинофильном эзофагите динамично меняются: появляются новые данные об эпидемиологии, патогенезе, диагностике и лечении, полученные в ходе крупных обсервационных и клинических исследований. С другой стороны, в литературе практически отсутствуют данные об иммуноглобулин (Ig)G4-связанном поражении пищевода. В статье приведен клинический случай: история развития язвы и стриктуры пищевода у молодого человека 17 лет. Описаны трудности диагностики и лечения, представлены современные данные о взаимосвязи эозинофильного эзофагита и патологического IgG4-ответа.

Keywords: IgG4-related disease; case report; eosinophilic esophagitis; immunoglobulin G4.

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