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. 2021 Jan 1;25(1):9-14.
doi: 10.1097/LGT.0000000000000582.

Survival of Older Women With Cervical Cancer Based on Screening History

Mitchell Clark  1 , Nathaniel Jembere  2 , Li Wang  2 , Rachel Kupets
Affiliations

Survival of Older Women With Cervical Cancer Based on Screening History

Mitchell Clark et al. J Low Genit Tract Dis. .

Abstract

Objective: A population-level retrospective cohort study was conducted to determine the influence of cervical screening history on the survival from cervical cancer in women 50 years or older.

Methods: The study included women diagnosed with invasive cervical cancer in Ontario, Canada, between 2005 and 2012, who were followed for at least 4 years. Screening history was observed for the 5 years before diagnosis. Health care administrative databases were linked to determine demographic, affiliation with primary care physicians, stage (available 2010-2012), treatment, and survival data. Kaplan-Meier and multivariate analyses were carried out to evaluate the impact of cervical screening on overall survival (OS).

Results: There were eligible 1,422 women diagnosed with invasive cervical cancer between 2005 and 2012 of whom 566 had been screened within the 5 years before diagnosis. There were 856 women who did not undergo screening within the 5 years before diagnosis. Unscreened women were more likely to present with locally advanced disease (69.3%) compared with the screened women (42.9%). Four-year OS was significantly greater in the screened group (79.9% vs 58.2%). In our univariate analysis, screening was significantly related to survival (hazard ratio = 2.1, p < .01). In our multivariate analysis after adjusting for age, treatment, affiliation with a primary care physician, and income, screening was still significantly associated with improved survival (hazard ratio = 1.5, p < .01).

Conclusions: Our results demonstrate a survival benefit to screening in women 50 years or older who are diagnosed with cervical cancer. Screening participation must be encouraged in women older than 50 years as rates decline in this age group.

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Conflict of interest statement

The authors have declared they have no conflicts of interest.

References

    1. Society, A.C. Key Statistics for Cervical Cancer. 2019. Available at: https://www.cancer.org/cancer/cervical-cancer/about/key-statistics.html . Accessed March 26, 2019.
    1. Canada, P.H.A.o. Cervical Cancer. 2017. Available at: https://www.canada.ca/en/public-health/services/chronic-diseases/cancer/... . Accessed March 26, 2019.
    1. Andrae B, Andersson TM-L, Lambert PC, et al. Screening and cervical cancer cure: population based cohort study. BMJ 2012;344:e900.
    1. Plummer M, de Martel C, Vignat J, et al. Global burden of cancers attributable to infections in 2012: a synthetic analysis. Lancet Glob Health 2016;4:e609–16.
    1. Vicus D, Sutradhar R, Lu Y, et al. Association between cervical screening and prevention of invasive cervical cancer in Ontario: a population-based case-control study. Int J Gynecol Cancer 2015;25:106–11.