Cardio-Oncology: A Win-Win Situation: How Solving the Mystery of an Ibrutinib Off-Target Effect Reveals New Insights Into Atrial Fibrillation Mechanisms

Farrukh T Awan^{1

2}, Dan Tong^{3

4}, Vlad G Zaha^{3

2

5

4}

Affiliations

¹ Hematology and Oncology Division (F.T.A.), University of Texas Southwestern Medical Center, Dallas.
² Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center (F.T.A., V.G.Z.), University of Texas Southwestern Medical Center, Dallas.
³ Cardiology Division (D.T., V.G.Z.), University of Texas Southwestern Medical Center, Dallas.
⁴ Parkland Health and Hospital System, Dallas, TX (D.T., V.G.Z.).
⁵ Advanced Imaging Research Center (V.G.Z.), University of Texas Southwestern Medical Center, Dallas.

Editorial

Farrukh T Awan et al. Circulation. 2020.

. 2020 Dec 22;142(25):2456-2458.

doi: 10.1161/CIRCULATIONAHA.120.052047. Epub 2020 Dec 21.

Farrukh T Awan^{1

2}, Dan Tong^{3

4}, Vlad G Zaha^{3

2

5

4}

¹ Hematology and Oncology Division (F.T.A.), University of Texas Southwestern Medical Center, Dallas.
² Department of Internal Medicine, Harold C. Simmons Comprehensive Cancer Center (F.T.A., V.G.Z.), University of Texas Southwestern Medical Center, Dallas.
³ Cardiology Division (D.T., V.G.Z.), University of Texas Southwestern Medical Center, Dallas.
⁴ Parkland Health and Hospital System, Dallas, TX (D.T., V.G.Z.).
⁵ Advanced Imaging Research Center (V.G.Z.), University of Texas Southwestern Medical Center, Dallas.

No abstract available

Keywords: CSK tyrosine-protein kinase; Editorials; atrial fibrillation; src-family kinases.

Comment on

Ibrutinib-Mediated Atrial Fibrillation Attributable to Inhibition of C-Terminal Src Kinase.
Xiao L, Salem JE, Clauss S, Hanley A, Bapat A, Hulsmans M, Iwamoto Y, Wojtkiewicz G, Cetinbas M, Schloss MJ, Tedeschi J, Lebrun-Vignes B, Lundby A, Sadreyev RI, Moslehi J, Nahrendorf M, Ellinor PT, Milan DJ. Xiao L, et al. Circulation. 2020 Dec 22;142(25):2443-2455. doi: 10.1161/CIRCULATIONAHA.120.049210. Epub 2020 Oct 23. Circulation. 2020. PMID: 33092403 Free PMC article.