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. 2021 May 1;203(9):1188-1190.
doi: 10.1164/rccm.202011-4253LE.

Continuous Positive Airway Pressure Restores Declarative Memory Deficit in Obstructive Sleep Apnea

Ina E Djonlagic  1 , Meng Guo  1   2 , Moroke Igue  1 , Divya Kishore  1 , Robert Stickgold  1 , Atul Malhotra  3
Affiliations

Continuous Positive Airway Pressure Restores Declarative Memory Deficit in Obstructive Sleep Apnea

Ina E Djonlagic et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Overnight improvement on the declarative Verbal Paired-Associates (VPA) task for patients with obstructive sleep apnea (OSA), who were randomized to treatment with continuous positive airway pressure (CPAP) and lifestyle changes for 3 months (CPAP group, n = 15), patients with OSA who implemented lifestyle changes for 3 months (no-CPAP, n = 16), and healthy control subjects (n = 36). Baseline performance for all groups (blue) and performance after 3 months are displayed for the CPAP (orange) and no-CPAP (white) group. Mean overnight VPA improvement between initial baseline and after 3 months of treatment intervention demonstrated a significant improvement for the CPAP group (P = 0.01) but not for the no-CPAP group (P = 0.14), with a significant difference in mean improvement over time between groups (P = 0.02). After 3 months of treatment, the CPAP group achieved performance levels similar to those of healthy control subjects (13.2% vs. 13.9%; P = 0.78).
See this image and copyright information in PMC

Comment in

  • Can N3 Period Duration Serve as a Predictor of Cognitive Dysfunction?
    Zheng Z, Chen R, Hong C, Lu J, Zhuang C, Liu H, Zhong Y, Zhang N. Zheng Z, et al. Am J Respir Crit Care Med. 2021 Nov 15;204(10):1235-1236. doi: 10.1164/rccm.202105-1231LE. Am J Respir Crit Care Med. 2021. PMID: 34478349 Free PMC article. No abstract available.
  • Reply to Zheng et al.
    Djonlagic IE, Guo M, Igue M, Kishore D, Stickgold R, Malhotra A. Djonlagic IE, et al. Am J Respir Crit Care Med. 2021 Nov 15;204(10):1236-1237. doi: 10.1164/rccm.202106-1414LE. Am J Respir Crit Care Med. 2021. PMID: 34478350 Free PMC article. No abstract available.

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