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Randomized Controlled Trial
. 2021 Jun;141(6):1601-1604.e2.
doi: 10.1016/j.jid.2020.12.009. Epub 2021 Jan 8.

Lack of Systemic Absorption of Topical Mechlorethamine Gel in Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma

Christiane Querfeld  1 , Larisa J Geskin  2 , Ellen J Kim  3 , Julia J Scarisbrick  4 , Pietro Quaglino  5 , Evangelia Papadavid  6 , James T Angello  7 , Pablo L Ortiz-Romero  8
Affiliations
Randomized Controlled Trial

Lack of Systemic Absorption of Topical Mechlorethamine Gel in Patients with Mycosis Fungoides Cutaneous T-Cell Lymphoma

Christiane Querfeld et al. J Invest Dermatol. 2021 Jun.
No abstract available

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References

    1. Kim YH, Martinez G, Varghese A, Hoppe RT. Topical nitrogen mustard in the management of mycosis fungoides: update of the Stanford experience. Arch Dermatol 2003;139:165–73. - PubMed
    1. Kim YH, Duvic M, Guitart J, Lessin S. Efficacy and safety of mechlorethamine (MCH) 0.04% gel in mycosis fungoides (MF) after treatment with topical MCH 0.02%. J Clin Oncol 2014;32:9093 (Abstr).
    1. Ledaga [summary of product characteristics]. 2018. https://www.ema.europa.eu/en/documents/product-information/ledaga-epar-p.... Accessed August 21, 2020.
    1. Lessin SR, Duvic M, Guitart J, Pandya AG, Strober BE, Olsen EA, et al. Topical chemotherapy in cutaneous T-cell lymphoma: positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02%, gel in mycosis fungoides. JAMA Dermatol 2013;149:25–32. - PMC - PubMed
    1. Lindahl LM, Fenger-Grøn M, Iversen L. Secondary cancers, comorbidities and mortality associated with nitrogen mustard therapy in patients with mycosis fungoides: a 30-year population-based cohort study. Br J Dermatol 2014;170:699–704. - PubMed