The use of atropine for treatment of amblyopia using the OptumLabs Data Warehouse

Stacy L Pineles¹, Michael X Repka², Fei Yu³, Federico G Velez⁴, Claudia Perez⁵, Danielle Sim⁵, Anne L Coleman⁶

Affiliations

¹ Department of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, California; OptumLabs Visiting Fellow, Cambridge, Massachusetts.
² Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
³ Department of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, California; Department of Biostatistics, University of California Los Angeles Fielding School of Public Health, Los Angeles, California.
⁴ Department of Ophthalmology, Doheny Eye Institute, University of California, Los Angeles, California; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina.
⁵ Department of Medicine Statistics Core, David Geffen School of Medicine, University of California, Los Angeles, California.
⁶ Department of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, California; Department of Epidemiology, University of California Los Angeles Fielding School of Public Health, Los Angeles, California.

PMID: 33348039
PMCID: PMC9037612
DOI: 10.1016/j.jaapos.2020.11.003

The use of atropine for treatment of amblyopia using the OptumLabs Data Warehouse

Stacy L Pineles et al. J AAPOS. 2021 Apr.

. 2021 Apr;25(2):107-109.e1.

doi: 10.1016/j.jaapos.2020.11.003. Epub 2021 Feb 15.

Authors

Stacy L Pineles¹, Michael X Repka², Fei Yu³, Federico G Velez⁴, Claudia Perez⁵, Danielle Sim⁵, Anne L Coleman⁶

Affiliations

¹ Department of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, California; OptumLabs Visiting Fellow, Cambridge, Massachusetts.
² Department of Ophthalmology, Wilmer Eye Institute, The Johns Hopkins University School of Medicine, Baltimore, Maryland.
³ Department of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, California; Department of Biostatistics, University of California Los Angeles Fielding School of Public Health, Los Angeles, California.
⁴ Department of Ophthalmology, Doheny Eye Institute, University of California, Los Angeles, California; Department of Ophthalmology, Duke University School of Medicine, Durham, North Carolina.
⁵ Department of Medicine Statistics Core, David Geffen School of Medicine, University of California, Los Angeles, California.
⁶ Department of Ophthalmology, Stein Eye Institute, University of California, Los Angeles, California; Department of Epidemiology, University of California Los Angeles Fielding School of Public Health, Los Angeles, California.

PMID: 33348039
PMCID: PMC9037612
DOI: 10.1016/j.jaapos.2020.11.003

Abstract

Atropine and patching are standard treatments for amblyopia, but the prevalence of atropine therapy in the United States is unknown. This study used the OptumLabs Data Warehouse to evaluate pharmacy claims for topical atropine to evaluate the frequency of its treatment for amblyopia and to compare demographic factors in cohorts of amblyopic children who were and were not prescribed atropine. Overall, 55.2% of amblyopic children were prescribed atropine more than once. The children who were prescribed atropine had a higher likelihood of living in geographic regions in the South or Midwest.

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References

1. Friedman DS, Repka MX, Katz J, et al. Prevalence of amblyopia and strabismus in white and African American children aged 6 through 71 months the Baltimore Pediatric Eye Disease Study. Ophthalmology 2009;116:2128–2134.e1–2. - PMC - PubMed
1. Multi-ethnic Pediatric Eye Disease Study Group. Prevalence of amblyopia and strabismus in African American and Hispanic children ages 6 to 72 months the multi-ethnic pediatric eye disease study. Ophthalmology 2008;115:1229–1236.e1. - PMC - PubMed
1. Pediatric Eye Disease Investigator Group. A randomized trial of atropine vs. patching for treatment of moderate amblyopia in children. Arch Ophthalmol 2002;120:268–78. - PubMed
1. Repka MX, Cotter SA, Beck RW, et al., Pediatric Eye Disease Investigator Group. A randomized trial of atropine regimens for treatment of moderate amblyopia in children. Ophthalmology 2004;111: 2076–85. - PubMed
1. Repka MX, Kraker RT, Beck RW, et al., Pediatric Eye Disease Investigator Group. Treatment of severe amblyopia with weekend atropine: results from 2 randomized clinical trials. J AAPOS 2009;13: 258–63. - PMC - PubMed

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The use of atropine for treatment of amblyopia using the OptumLabs Data Warehouse

Affiliations

The use of atropine for treatment of amblyopia using the OptumLabs Data Warehouse

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical