Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Feb;17(2):75-76.
doi: 10.1038/s41584-020-00566-y.

MIS-C: early lessons from immune profiling

Lauren A Henderson  1 , Rae S M Yeung  2
Affiliations
Review

MIS-C: early lessons from immune profiling

Lauren A Henderson et al. Nat Rev Rheumatol. 2021 Feb.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a rare complication of SARS-CoV-2 infection that can result in serious illness in the paediatric population but our understanding of this syndrome is in its infancy. Translational studies in 2020 leveraging immune profiling have laid the foundation to enable further discovery in MIS-C.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Emerging clinical and immunological features of MIS-C.
Multiple organs are affected in multisystem inflammatory syndrome in children (MIS-C). Most patients have evidence of prior SARS-CoV-2 exposure, and Kawasaki disease features and cardiac dysfunction are common. The immune response in MIS-C is distinct from that during the acute SARS-CoV-2 infection, and is associated with elevated pro-inflammatory cytokines, activated neutrophils and monocytes, cytopenias (thrombopenia and lymphopenia) and appropriate anti-viral antibody responses detected to SARS-CoV-2.
See this image and copyright information in PMC

References

    1. Riphagen S, Gomez X, Gonzalez-Martinez C, Wilkinson N, Theocharis P. Hyperinflammatory shock in children during COVID-19 pandemic. Lancet. 2020;395:1607–1608. doi: 10.1016/S0140-6736(20)31094-1. - DOI - PMC - PubMed
    1. Verdoni L, et al. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. Lancet. 2020;395:1771–1778. doi: 10.1016/S0140-6736(20)31103-X. - DOI - PMC - PubMed
    1. Dufort EM, et al. Multisystem inflammatory syndrome in shildren in New York State. New Engl. J. Med. 2020;383:347–358. doi: 10.1056/NEJMoa2021756. - DOI - PMC - PubMed
    1. Feldstein LR, et al. Multisystem inflammatory syndrome in U.S. children and adolescents. New Engl. J. Med. 2020;383:334–346. doi: 10.1056/NEJMoa2021680. - DOI - PMC - PubMed
    1. Abrams JY, et al. Multisystem inflammatory syndrome in children associated with severe acute respiratory syndrome coronavirus 2: a systematic review. J. Pediatr. 2020;226:45–54. doi: 10.1016/j.jpeds.2020.08.003. - DOI - PMC - PubMed

MeSH terms

Supplementary concepts