Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 Mar;17(2):472-495.
doi: 10.1111/1541-4337.12335. Epub 2018 Feb 7.

Natural Products for Prevention and Treatment of Chemical-Induced Liver Injuries

Xiao Meng  1 , Ya Li  1 , Sha Li  2 , Ren-You Gan  3 , Hua-Bin Li  1   4
Affiliations

Natural Products for Prevention and Treatment of Chemical-Induced Liver Injuries

Xiao Meng et al. Compr Rev Food Sci Food Saf. 2018 Mar.

Abstract

Chemicals (such as alcohol, drugs, and pollutants) may cause liver injuries, which could consequently develop into fatty liver, hepatitis, fibrosis, cirrhosis, and liver failure, or even cancers. Liver injuries have been a serious public health problem worldwide. Numerous natural products and their bioactive components have shown protective action for liver injuries, such as blueberry, cactus fruits, Pueraria lobate, betaine, and silymarin. The underlying mechanisms mainly include antioxidation, anti-inflammation, anti-apoptosis, anti-necrosis, repairing damaged DNA, regulating the metabolism of lipids, and modulating primary bile acid biosynthesis. This review summarizes the natural products and bioactive compounds with protective effects on liver injuries caused by chemicals, and special attention is paid to the mechanisms of action. This updated information can be helpful to prevent and treat liver-related diseases, especially chemical-induced liver injuries.

Keywords: chemical; food; liver injuries; medicinal herbs; natural products.

PubMed Disclaimer

References

    1. Adebayo, A. H., Song, F. H., Liu, X. T., Dai, Q. H., Huang, P., Zhang, J. Y., & Zhang, L. X. (2014). Citrullus lanatus extract reverses oxidative and haematological dysfunction in carbon tetrachloride induced liver damaged rats. International Journal of Pharmacology, 10(4), 218-224.
    1. Adeyemi, D. O., Ukwenya, V. O., Obuotor, E. M., & Adewole, S. O. (2014). Anti-hepatotoxic activities of Hibiscus sabdariffa L. in animal model of streptozotocin diabetes-induced liver damage. BMC Complementary and Alternative Medicine, 14(1), 1-11.
    1. Ahn, M., Park, J. S., Chae, S., Kim, S., Moon, C., Hyun, J. W., & Shin, T. (2014). Hepatoprotective effects of Lycium chinense Miller fruit and its constituent betaine in CCl4-induced hepatic damage in rats. Acta Histochemica, 116(6), 1104-1112.
    1. Ahn, M., Kim, J., Bang, H., Moon, J., Kim, G. O., & Shin, T. (2016). Hepatoprotective effects of allyl isothiocyanate against carbon tetrachloride-induced hepatotoxicity in rat. Chemico-Biological Interactions, 254, 102-108.
    1. Akacha, A., Rebai, T., Amri, M., & Zourgui, L. (2013). Preventive role of Cactus (Opuntia ficus-indica) Cladodes on methotrexate induced biochemical, hematological and oxidative damage in rat liver. Acta Horticulturae, 995, 285-295.

LinkOut - more resources