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Review
. 2021 May;51(5):e13482.
doi: 10.1111/eci.13482. Epub 2021 Jan 6.

Lactation as a programming window for metabolic syndrome

Catalina Picó  1   2   3 , Flávio Reis  4   5   6 , Conceição Egas  5   7 , Paulo Mathias  8 , Paulo Matafome  5   6   9   10
Affiliations
Review

Lactation as a programming window for metabolic syndrome

Catalina Picó et al. Eur J Clin Invest. 2021 May.

Abstract

The concept of developmental origins of health and disease (DOHaD) was initially supported by the low birth weight and higher risk of developing cardiovascular disease in adult life, caused by nutrition restriction during foetal development. However, other programming windows have been recognized in the last years, namely lactation, infancy, adolescence and even preconception. Although the concept has been developed in order to study the impact of foetal calorie restriction in adult life, it is now recognized that maternal overweight during programming windows is also harmful to the offspring. This article explores and summarizes the current knowledge about the impact of maternal obesity and obesogenic diets during lactation in the metabolic programming towards the development of metabolic syndrome in the adult life. The impact of maternal obesity and obesogenic diets in milk quality is discussed, including the alterations in specific micro and macronutrients, as well as the impact of such alterations in the development of metabolic syndrome-associated features in the newborn, such as insulin resistance and adiposity. Moreover, the impact of milk quality and formula feeding in infants' gut microbiota, immune system maturation and in the nutrient-sensing mechanisms, namely those related to gut hormones and leptin, are also discussed under the current knowledge.

Keywords: lactation; metabolic programming; milk composition; obesity.

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References

REFERENCES

    1. Barker DJ. Fetal origins of coronary heart disease. Br Heart J. 1993;69(3):195-196.
    1. Barker DJ, Thornburg K. The obstetric origins of health for a lifetime. Clin Obs Gynecol. 2013;56(3):511-519.
    1. De Oliveira JC, Lisboa PC, de Moura EG, et al. Poor pubertal protein nutrition disturbs glucose-induced insulin secretion process in pancreatic islets and programs rats in adulthood to increase fat accumulation. J Endocrinol. 2013;216(2):195-206. https://doi.org/10.1530/JOE-12-0408
    1. Agnoux AM, Antignac JP, Simard G, et al. Time window-dependent effect of perinatal maternal protein restriction on insulin sensitivity and energy substrate oxidation in adult male offspring. Am J Physiol - Regul Integr Comp Physiol. 2014;307(2):184-197.
    1. Sellayah D, Cagampang FR. The divergent effect of maternal protein restriction during pregnancy and postweaning high-fat diet feeding on blood pressure and adiposity in adult mouse offspring. Nutrients. 2018;10(12):1832.