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. 2021 Jan;27(1):294-296.
doi: 10.3201/eid2701.203527.

Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

Clara Bergmann, Welmoed van Loon, Felix Habarugira, Costanza Tacoli, Julia C Jäger, Darius Savelsberg, Fabian Nshimiyimana, Elias Rwamugema, Djibril Mbarushimana, Jules Ndoli, Augustin Sendegeya, Claude Bayingana, Frank P Mockenhaupt

Increase in Kelch 13 Polymorphisms in Plasmodium falciparum, Southern Rwanda

Clara Bergmann et al. Emerg Infect Dis. 2021 Jan.

Abstract

Artemisinin resistance in Plasmodium falciparum is associated with nonsynonymous mutations in the Kelch 13 (K13) propeller domain. We found that 12.1% (8/66) of clinical P. falciparum isolates from Huye district, Rwanda, exhibited K13 mutations, including R561H, a validated resistance marker. K13 mutations appear to be increasing in this region.

Keywords: Kelch; Plasmodium falciparum; antimicrobial resistance; artemisinin; malaria; mutation; parasites; polymorphism; vector-borne infections.

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