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Comment
. 2020 Dec 21;55(6):669-670.
doi: 10.1016/j.devcel.2020.11.023.

Cells under Tension Drive Gastrulation

Clayton Schwarz  1 , Anna-Katerina Hadjantonakis  2
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Cells under Tension Drive Gastrulation

Clayton Schwarz et al. Dev Cell. .
Free article

Abstract

In this issue of Developmental Cell, Muncie et al. describe the generation of gastrulation-like foci of cells within micropatterned colonies of pluripotent stem cells. This demonstration of mechanosensitive β-catenin/Wnt-dependent specification of cell fate during gastrulation illustrates the insights gleaned by placing stem cells in embryo-like mechanical environments.

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