Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Apr;48(2):157-171.
doi: 10.1111/iji.12523. Epub 2020 Dec 22.

Non-KIR NK cell receptors: Role in transplantation of allogeneic haematopoietic stem cells

Katarzyna Bogunia-Kubik  1 , Piotr Łacina  1
Affiliations
Review

Non-KIR NK cell receptors: Role in transplantation of allogeneic haematopoietic stem cells

Katarzyna Bogunia-Kubik et al. Int J Immunogenet. 2021 Apr.

Abstract

Natural killer (NK) cells are of major significance in patients after allogeneic haematopoietic stem cell transplantation (HSCT). They are the first subset of lymphocytes to appear in peripheral blood after transplantation and play an important role in the immune responses against cancer and viral infections. The function of NK cells is controlled by various surface receptors, of which type I integral proteins with immunoglobulin-like domains (killer-cell immunoglobulin-like receptors, KIRs) have been the most extensively studied. The present review focuses on less studied NK cell receptors, such as type II integral proteins with lectin-like domains (CD94/NKG2, NKG2D), natural cytotoxicity receptors (NCRs), immunoglobulin-like transcripts (ILTs) and their ligands. Their potential role in patients with haematological disorders subjected to HSC transplant procedure in the context of post-transplant complications such as viral reactivation and acute graft-versus-host disease (GvHD) will be presented and discussed.

PubMed Disclaimer

References

REFERENCES

    1. Alho, A. C., Kim, H. T., Chammas, M. J., Reynolds, C. G., Matos, T. R., Forcade, E., Whangbo, J., Nikiforow, S., Cutler, C. S., Koreth, J., Ho, V. T., Armand, P., Antin, J. H., Alyea, E. P., Lacerda, J. F., Soiffer, R. J., & Ritz, J. (2016). Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD. Blood, 127(5), 646-657. https://doi.org/10.1182/blood-2015-10-672345
    1. Anderson, E., Grzywacz, B., Wang, H., Wang, T., Haagenson, M., Spellman, S., Blazar, B. R., Miller, J. S., & Verneris, M. R. (2009). Limited role of MHC class I chain-related gene A (MICA) typing in assessing graft-versus-host disease risk after fully human leukocyte antigen-matched unrelated donor transplantation. Blood, 114(21), 4753-4755. https://doi.org/10.1182/blood-2009-08-239301
    1. Arnon, T. I., Lev, M., Katz, G., Chernobrov, Y., Porgador, A., & Mandelboim, O. (2001). Recognition of viral hemagglutinins by NKp44 but not by NKp30. European Journal of Immunology, 31(9), 2680-2689. https://doi.org/10.1002/1521-4141(200109)31:9<2680:aid-immu2680>3....
    1. Askar, M., Sun, Y., Rybicki, L., Zhang, A., Thomas, D., Kalaycio, M., Pohlman, B., Dean, R., Duong, H., Hanna, R., Maciejewski, J., Majhail, N. S., Bolwell, B., & Sobecks, R. (2014). Synergistic effect of major histocompatibility complex class I-related chain a and human leukocyte antigen-DPB1 mismatches in association with acute graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation. Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation, 20(11), 1835-1840. https://doi.org/10.1016/j.bbmt.2014.07.019
    1. Augugliaro, R., Parolini, S., Castriconi, R., Marcenaro, E., Cantoni, C., Nanni, M., Moretta, L., Moretta, A., & Bottino, C. (2003). Selective cross-talk among natural cytotoxicity receptors in human natural killer cells. European Journal of Immunology, 33(5), 1235-1241. https://doi.org/10.1002/eji.200323896

MeSH terms

Substances

LinkOut - more resources