NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion

Margaret J Ochocinska¹, Steven L Spitalnik², Alfred Abuhamad³, Elliott Bennett-Guerrero⁴, Waldemar A Carlo⁵, Murali Cherukuri⁶, Allan Doctor⁷, Walter Dzik⁸, Conor L Evans⁹, Erica Forzani¹⁰, Periannan Kuppusamy¹¹, Natacha Le Moan¹², Lei Li¹³, Naomi Luban¹⁴, Narla Mohandas¹⁵, Ravi M Patel¹⁶, John Roback¹⁷, Harold Swartz¹⁸, Stephen Textor¹⁹, Sergei Vinogradov²⁰, Lihong V Wang¹³, Natalie Wisniewski²¹, Simone Glynn²²

Affiliations

¹ Translational Blood Science and Resources Branch, Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
² Department of Pathology and Cell Biology, Columbia University, New York, NY, USA. Electronic address: ss2479@cumc.columbia.edu.
³ Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA, USA.
⁴ Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
⁵ Department of Pediatrics, UAB School of Medicine, Birmingham, AL, USA.
⁶ Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
⁷ Center for Blood Oxygen Transport and Hemostasis (CBOTH), University of Maryland, Baltimore, MD, USA; School of Medicine, Health Sciences Facility (HSF) III, Baltimore, MD, USA.
⁸ Blood Transfusion Service, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
⁹ Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
¹⁰ Biodesign Center for Bioelectronics and Biosensors, School for Engineering of Matter, Transport & Energy, Arizona State University, Tempe, AZ, USA.
¹¹ Departments of Radiology and Medicine, Geisel College of Medicine at Dartmouth, Lebanon, NH, USA.
¹² Catalyst Biosciences, South San Francisco, CA, USA.
¹³ Departments of Electrical Engineering and Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.
¹⁴ Department of Pediatrics, Children's National Medical Center, Washington, DC, USA.
¹⁵ New York Blood Center, New York, NY, USA.
¹⁶ Department of Pediatrics, Division of Neonatology, Emory University School of Medicine, Atlanta, GA, USA.
¹⁷ Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
¹⁸ Department of Radiology, Geisel College of Medicine at Dartmouth, Hanover, NH, USA.
¹⁹ Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
²⁰ Department of Biochemistry and Biophysics, Perelman School of Medicine, Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
²¹ Profusa, Inc., Emeryville, CA, USA.
²² Blood Epidemiology and Clinical Therapeutics Branch, Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.

PMID: 33353783
PMCID: PMC8325696
DOI: 10.1016/j.tmrv.2020.12.003

Review

NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion

Margaret J Ochocinska et al. Transfus Med Rev. 2021 Jan.

. 2021 Jan;35(1):46-55.

doi: 10.1016/j.tmrv.2020.12.003. Epub 2020 Dec 6.

Authors

Affiliations

¹ Translational Blood Science and Resources Branch, Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.
² Department of Pathology and Cell Biology, Columbia University, New York, NY, USA. Electronic address: ss2479@cumc.columbia.edu.
³ Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, VA, USA.
⁴ Department of Anesthesiology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.
⁵ Department of Pediatrics, UAB School of Medicine, Birmingham, AL, USA.
⁶ Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
⁷ Center for Blood Oxygen Transport and Hemostasis (CBOTH), University of Maryland, Baltimore, MD, USA; School of Medicine, Health Sciences Facility (HSF) III, Baltimore, MD, USA.
⁸ Blood Transfusion Service, Massachusetts General Hospital, Harvard University, Boston, MA, USA.
⁹ Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
¹⁰ Biodesign Center for Bioelectronics and Biosensors, School for Engineering of Matter, Transport & Energy, Arizona State University, Tempe, AZ, USA.
¹¹ Departments of Radiology and Medicine, Geisel College of Medicine at Dartmouth, Lebanon, NH, USA.
¹² Catalyst Biosciences, South San Francisco, CA, USA.
¹³ Departments of Electrical Engineering and Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, USA.
¹⁴ Department of Pediatrics, Children's National Medical Center, Washington, DC, USA.
¹⁵ New York Blood Center, New York, NY, USA.
¹⁶ Department of Pediatrics, Division of Neonatology, Emory University School of Medicine, Atlanta, GA, USA.
¹⁷ Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA.
¹⁸ Department of Radiology, Geisel College of Medicine at Dartmouth, Hanover, NH, USA.
¹⁹ Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
²⁰ Department of Biochemistry and Biophysics, Perelman School of Medicine, Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, PA, USA.
²¹ Profusa, Inc., Emeryville, CA, USA.
²² Blood Epidemiology and Clinical Therapeutics Branch, Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.

PMID: 33353783
PMCID: PMC8325696
DOI: 10.1016/j.tmrv.2020.12.003

No abstract available

Keywords: Blood transfusion; Oxygenation; Perfusion.

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Conflict of interest statement

Declaration of Interest

This costs of organizing the meeting and travel reimbursement for the invited speakers were provided by the National Heart, Lung, and Blood Institute. Nonetheless, the summaries contributed by each author represent their own opinions. Otherwise, the authors have no competing interests to declare.

References

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1. Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JCT, Fogerty AE, Waheed A, et al. COVID and coagulation: bleeding and thrombotic manifestations of SARS-CoV2 infection. Blood 2020;136:489–500. 10.1182/blood.2020006520. - DOI - PMC - PubMed
1. Thomas T, Stefanoni D, Dzieciatkowska M, Issaian A, Nemkov T, Hill RC, et al. Evidence for structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients. J Proteome Res 2020;19:4455–69. 10.1021/acs.jproteome.0c00606. - DOI - PMC - PubMed
1. Doctor A, Stamler JS. Nitric oxide transport in blood: a third gas in the respiratory cycle. Compr Physiol 2011;1:541–68. 10.1002/cphy.c090009. - DOI - PubMed
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NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion

Affiliations

NIH Workshop 2018: Towards Minimally Invasive or Noninvasive Approaches to Assess Tissue Oxygenation Pre- and Post-transfusion

Authors

Affiliations

Conflict of interest statement

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical