Sulphonamides in the treatment of acute Escherichia coli infection of the urinary tract in women. Clinical and ecological effects of sulphasomidine and sulphalene

Abstract

28 non-pregnant women were treated with conventional doses of sulphasomidine or sulphalene for acute urinary tract infections caused by Escherichia coli. Both preparations were found to be effective in simple cystitis infection with sulphonamide-sensitive organisms. Also, both were found to exert a selective pressure favouring sulphonamide-resistant E. coli in the faecal flora.