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. 2021 Apr 30;51(2):727-734.
doi: 10.3906/sag-2008-165.

Role of dyslipidemia in early vascular aging syndrome

Alparslan Kılıç  1 , Onur Baydar  1 , Deniz Elçik  2 , Ziya Apaydın  3 , Mehmet Mustafa Can  3
Affiliations

Role of dyslipidemia in early vascular aging syndrome

Alparslan Kılıç et al. Turk J Med Sci. .

Abstract

Background/aim: Arterial stiffness, known as a predictor of early vascular aging, was defined as the main determinant of cardiovascular mortality and morbidity. However, the relationship between lipid profile and increased arterial stiffness is not clear. The aim of this study is to investigate the relationship between lipid profiles and increased arterial stiffness in patients with early vascular aging syndrome.

Materials and methods: A total of 1582 participants —504 (31.8%) of were male and the mean age was 52.8 ±14.2 years— were included in the study . Patients who applied to the hospital for various reasons and who had undergone 24-h blood pressure Holter monitoring were included in this study. Patients were divided into four groups according to pulse wave velocity (PWV) quartiles (Q1 (<6.3), Q2 (6.3–7.4), Q3 (7.5–8.8), Q4 (>8.8)).

Results: We found that in the highest PWV group, patients had higher systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, blood urea nitrogen (BUN), creatinine, urinary albumin excretion (UAE), uric acid(UA), total cholesterol (TC), low-density lipoprotein ( LDL-C), triglycerid (TG), and non- high-density lipoprotein (HDL-C ) levels. Additionally, diabetes mellitus (dm), age, non-HDL-C, and TG/ HDL-C levels were detected as independent risk factors of increased PWV in ordinal logistic regression analysis.

Conclusion: Our study demonstrates that lipid parameters are strongly correlated with increased PWVvalue and early vascular aging. In daily clinical practice, TG\HDL-C ratio, known as atherogenic index, might be used routinely for predicted of early vascular aging and subclinical atherosclerosis.

Keywords: Arterial stiffness; vascular aging; lipid profile.

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Conflict of interest statement

None declared.

Figures

Figure
Figure
Study design
See this image and copyright information in PMC

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