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. 2022 Mar;36(5):1182-1190.
doi: 10.1080/14786419.2020.1864365. Epub 2020 Dec 28.

A new antidiabetic and anti-inflammatory biflavonoid from Schinus polygama (Cav.) Cabrera leaves

Heba A S El-Nashar  1 , Nada M Mostafa  1 , Omayma A Eldahshan  1   2 , Abdel Nasser B Singab  1   2
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A new antidiabetic and anti-inflammatory biflavonoid from Schinus polygama (Cav.) Cabrera leaves

Heba A S El-Nashar et al. Nat Prod Res. 2022 Mar.

Abstract

A new biflavonoid, luteolin-(6→8'')-apigenin was isolated from 80% methanol extract of Schinus polygama (Cav.) Cabrera leaves (Anacardiaceae). The structure was elucidated by 1D and 2D-NMR spectroscopic data. This compound exhibited in vitro antidiabetic effect via α-amylase assay. Furthermore, it possesses anti-inflammatory activity through membrane stabilization effect on erythrocytes.

Keywords: Schinus polygama; amylase; anti-inflammatory; biflavonoid; membrane stabilization.

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