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Review
. 2021;14(4):315-324.
doi: 10.2174/1874471013666201224113651.

A Review of Accelerator-Produced Ga-68 with Solid Targets

Kaelyn V Becker  1 , Margarita Chernysheva  1 , Todd E Barnhart  1 , Katherine Gagnon  2 , Jonathan W Engle  1
Affiliations
Free article
Review

A Review of Accelerator-Produced Ga-68 with Solid Targets

Kaelyn V Becker et al. Curr Radiopharm. 2021.
Free article

Abstract

Gallium-68 is a positron-emitting nuclide that has recently achieved clinical acceptance as the diagnostic radionuclide in PET tracers used for theranostic studies of lutetium-177 labeled therapeutic drugs due to the ease of access provided by germanium-68/gallium-68 generators. An alternative method of production currently being explored uses accelerators to form gallium-68 directly. This review of gallium-68 production strategies discusses available accelerator targetry at a range of beam energies and intensities, the many radiochemical separation techniques available to isolate Ga-68 from irradiated targets, isotopically enriched target material recovery, and the implications of these techniques for downstream radiolabeling applications.

Keywords: Lu-177 labeled.; PET; Radiochemical; gallium-68; radiochemistry; therapeutic molecule.

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