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Comment
. 2020 Dec 23;183(7):1739-1741.
doi: 10.1016/j.cell.2020.11.039.

Fighting for Fat: Gluttonous Tumors and Starved T Cells

Joshua H Goodman  1 , Anthony W Ferrante Jr  2
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Fighting for Fat: Gluttonous Tumors and Starved T Cells

Joshua H Goodman et al. Cell. .
Free article

Abstract

In this issue of Cell, Ringel et al. reveal a link between lipid utilization in the tumor microenvironment and anti-tumor immunity in obese mice. These findings provide one explanation for how obesity worsens cancer outcomes and may point to a new metabolic approach to treating some cancers.

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  • Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity.
    Ringel AE, Drijvers JM, Baker GJ, Catozzi A, García-Cañaveras JC, Gassaway BM, Miller BC, Juneja VR, Nguyen TH, Joshi S, Yao CH, Yoon H, Sage PT, LaFleur MW, Trombley JD, Jacobson CA, Maliga Z, Gygi SP, Sorger PK, Rabinowitz JD, Sharpe AH, Haigis MC. Ringel AE, et al. Cell. 2020 Dec 23;183(7):1848-1866.e26. doi: 10.1016/j.cell.2020.11.009. Epub 2020 Dec 9. Cell. 2020. PMID: 33301708 Free PMC article.

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