Glutamate and Gamma-Aminobutyric Acid Abnormalities in Antipsychotic-Naïve Patients With Schizophrenia: Evidence From Empirical and Meta-analytic Studies Using Magnetic Resonance Spectroscopy
- PMID: 33357632
- PMCID: PMC8221118
- DOI: 10.1016/j.biopsych.2020.11.005
Glutamate and Gamma-Aminobutyric Acid Abnormalities in Antipsychotic-Naïve Patients With Schizophrenia: Evidence From Empirical and Meta-analytic Studies Using Magnetic Resonance Spectroscopy
Conflict of interest statement
The author reports no biomedical financial interests or potential conflicts of interest.
Comment on
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Associations Between Cognitive Function and Levels of Glutamatergic Metabolites and Gamma-Aminobutyric Acid in Antipsychotic-Naïve Patients With Schizophrenia or Psychosis.Biol Psychiatry. 2021 Feb 1;89(3):278-287. doi: 10.1016/j.biopsych.2020.06.027. Epub 2020 Jul 10. Biol Psychiatry. 2021. PMID: 32928500 Free PMC article.
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Glutamate in the Dorsolateral Prefrontal Cortex in Patients With Schizophrenia: A Meta-analysis of 1H-Magnetic Resonance Spectroscopy Studies.Biol Psychiatry. 2021 Feb 1;89(3):270-277. doi: 10.1016/j.biopsych.2020.09.001. Epub 2020 Sep 8. Biol Psychiatry. 2021. PMID: 33129486
References
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- Bojesen KB, Broberg BV, Fagerlund B, Jessen K, Thomas MB, Sigvard A, et al. (2021): Associations between cognitive function and levels of glutamatergic metabolites and gamma-aminobutyric acid in antipsychotic-naive patients with schizophrenia or psychosis. Biol Psychiatry. 89:278–287. - PMC - PubMed
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- Kaminski J, Mascarell-Maricic L, Fukuda Y, Katthagen T, Heinz A, Schlagenhauf F (2021): Glutamate in dorsolateral prefrontal cortex in patients with schizophrenia: A meta-analysis of 1-HMRS studies. Biol Psychiatry. 89:270–277. - PubMed
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- Jelen LA, King S, Horne CM, Lythgoe DJ, Young AH, Stone JM (2019): Functional magnetic resonance spectroscopy in patients with schizophrenia and bipolar affective disorder: Glutamate dynamics in the anterior cingulate cortex during a working memory task. Eur Neuropsychopharmacol. 29:222–234. - PubMed
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