Disclosure PB reports receipt of advisory board or conference honoraria from Merck, Sanofi, Merck Sharp & Dohme, Sun Pharma, Angelini, AstraZeneca, Bristol Myers Squibb, Helsinn, GlaxoSmithKline. ATC reports receipt of grants/research support from Pfizer, Eli Lilly, Novartis, Merck Serono, Merck Sharp & Dohme; receipt of honoraria for participation in an advisory board for Merck Sharp & Dohme; receipt of honoraria for the provision of consultancy services for Merck Serono, Merck Sharp & Dohme, Cullinan Management Inc. LL reports receipt of honoraria or consultancy fees (for public speaking/teaching in medical meetings and/or for expert opinion in advisory boards) from AstraZeneca, Bayer, Bristol Myers Squibb, Eisai, Merck Sharp & Dohme, Merck Serono, Boehringer Ingelheim, Novartis, Roche, Debiopharm International SA, Sobi, Ipsen, Incyte Biosciences Italy srl, Doxa Pharma, Amgen, Nanobiotics Sa and GlaxoSmithKline; receipt of grants/research support (funds received by the institution for clinical studies and research activities) from AstraZeneca, Bristol Myers Squibb, Boehringer Ingelheim, Celgene International, Debiopharm International SA, Eisai, Exelixis Inc., Hoffmann-La Roche Ltd, IRX Therapeutics Inc., Medpace Inc., Merck Serono, Merck Sharp & Dohme, Novartis, Pfizer and Roche. EPH reports receipt of speaker's honoraria from Merck Sharp & Dohme and Merck Serono; participation in a scientific advisory board for Merck Sharp & Dohme. JHal reports receipt of research support to Masaryk Memorial Cancer Institute from the Ministry of Health of the Czech Republic, MZ ČR - RVO (MOÚ, 00209805) and CZECRIN LM2018128. BB reports receipt of honoraria for participation in scientific advisory boards for AstraZeneca, Merck Sharp & Dohme, Merck Serono. CvH reports receipt of grants/research support to their institution from AstraZeneca, Bristol Myers Squibb, Merck Sharp & Dohme, Merck, Ipsen, Novartis and Sanofi; receipt of honoraria for participation in a scientific advisory board from Bayer, Bristol Myers Squibb, Ipsen, Merck Sharp & Dohme and Regeneron. AC reports receipt of grants/research support to their institution from Merck; participation in a sponsored speakers' bureau for Merck, Bristol Myers Squibb and Merck Sharp & Dohme; receipt of honoraria for participation in a scientific advisory board from Merck, Bristol Myers Squibb and Merck Sharp & Dohme; lecture fees from Bristol Myers Squibb, Merck Sharp & Dohme and Merck. J-PM reports acting in an advisory role for Merck Serono and Merck Sharp & Dohme. AT, EO, SM, JHar and LS have declared no potential conflicts of interest.