Pandemic trials: evidence-based medicine on steroids
- PMID: 33361452
- PMCID: PMC7758540
- DOI: 10.1183/13993003.04116-2020
Pandemic trials: evidence-based medicine on steroids
Abstract
Small trials have been largely overlooked in the early part of the COVID-19 pandemic in favour of “mega-trials”. As new therapies are urgently needed, phase 2 “proof of concept” studies are crucial as we move into a new phase of pandemic research.
Conflict of interest statement
Conflict of interest: J.D. Chalmers reports grants and personal fees from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline and Insmed, personal fees from Chiesi, Novartis and Zambon, grants from Gilead Sciences, outside the submitted work.
Comment on
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Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial.Eur Respir J. 2020 Dec 24;56(6):2002808. doi: 10.1183/13993003.02808-2020. Print 2020 Dec. Eur Respir J. 2020. PMID: 32943404 Free PMC article. Clinical Trial.
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