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Review
. 2020 Dec 8:11:491895.
doi: 10.3389/fgene.2020.491895. eCollection 2020.

How Can Drug Metabolism and Transporter Genetics Inform Psychotropic Prescribing?

Beatriz Carvalho Henriques  1 , Esther H Yang  1   2 , Diego Lapetina  1   2 , Michael S Carr  1 , Vasyl Yavorskyy  1 , Joshua Hague  1   2 , Katherine J Aitchison  1   2   3
Affiliations
Review

How Can Drug Metabolism and Transporter Genetics Inform Psychotropic Prescribing?

Beatriz Carvalho Henriques et al. Front Genet. .

Abstract

Many genetic variants in drug metabolizing enzymes and transporters have been shown to be relevant for treating psychiatric disorders. Associations are strong enough to feature on drug labels and for prescribing guidelines based on such data. A range of commercial tests are available; however, there is variability in included genetic variants, methodology, and interpretation. We herein provide relevant background for understanding clinical associations with specific variants, other factors that are relevant to consider when interpreting such data (such as age, gender, drug-drug interactions), and summarize the data relevant to clinical utility of pharmacogenetic testing in psychiatry and the available prescribing guidelines. We also highlight areas for future research focus in this field.

Keywords: cytochrome P450 enzymes; drug metabolism; drug transporters; pharmacogenomics (PGx); psychotropic drugs.

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Conflict of interest statement

KA is a member of the Pharmacogene Variation Consortium, Clinical Pharmacogenetics Implementation Consortium, has received two research grants in the last two years from Janssen Inc., Canada (fellowship grants for trainees) and provided consultancy services (unpaid) for HLS Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
CYP enzyme families most relevant to psychotropic drug metabolism.
See this image and copyright information in PMC

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