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Case Reports
. 2020 Aug 10;8(12):2578-2582.
doi: 10.1002/ccr3.3239. eCollection 2020 Dec.

Multiple cutaneous ulcers revealing a primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma

Billal Tedbirt  1 , Sydney Dubois  2 , Lucie Cellier  3 , Priscille Carvalho  1 , Aspasia Stamatoullas  2 , Philippe Courville  3 , Aurélie Deschamps-Huvier  1 , Pascaline Etancelin  4 , Anne Deniel  5 , Hervé Tilly  2 , Fabrice Jardin  2 , Pascal Joly  1 , Vincent Camus  2
Affiliations
Case Reports

Multiple cutaneous ulcers revealing a primary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma

Billal Tedbirt et al. Clin Case Rep. .

Abstract

Primary cutaneous EBV-positive diffuse large B-cell lymphoma is an exceptional and aggressive neoplasia with a poorer prognosis than other cutaneous lymphoma. Our observation points out the rarity of the presentation and the dismal clinical course.

Keywords: Epstein‐Barr virus; cutaneous lymphoma; cutaneous ulcers.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Large deep ulcers on the right lower leg (A), back (B) and left forearm (C)
Figure 2
Figure 2
Skin biopsy showed atypical B cells in the dermis with large basophilic cytoplasm, irregular and vesicular chromatin (hematoxylin‐eosin‐saffron stain, A, original magnification ×20, B, original magnification ×40)
Figure 3
Figure 3
Immunohistochemical staining showed positivity for CD20 (A), EBER (B) and MUM‐1 (C) and a high Ki67 labelling index (D) (original magnification ×20)
Figure 4
Figure 4
18F‐fluorodeoxyglucose positron‐emission tomography revealed hypermetabolic spleen (A) and bilateral hilar and mediastinal (B) involvement and several cutaneous and subcutaneous localizations (C: lower limbs, axial view; D: whole body, coronal view)
See this image and copyright information in PMC

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