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Case Reports
. 2020 Sep 8;8(12):2869-2873.
doi: 10.1002/ccr3.3310. eCollection 2020 Dec.

Light-chain amyloid myopathy isolated to skeletal muscles: A case report

Toshihiro Matsukawa  1 , Katsuki Eguchi  2 , Ichizo Nishino  3 , Kohei Okada  1 , Kazuo Oshimi  1 , Takuto Miyagishima  1
Affiliations
Case Reports

Light-chain amyloid myopathy isolated to skeletal muscles: A case report

Toshihiro Matsukawa et al. Clin Case Rep. .

Abstract

Isolated amyloidosis, especially of amyloid light-chain type, is an infrequent disease. Systemic chemotherapy for light-chain amyloidosis isolated to skeletal muscles plays a key role to reduce clonal plasma cells producing aberrant immunoglobulin.

Keywords: amyloidosis; isolated amyloid myopathy; light‐chain.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Representative pathological images of a rectus femoris muscle biopsy. On hematoxylin and eosin (A), fiber size variation is mild. On nicotinamide adenine dinucleotide tetrazolium reductase (B), intermyofibrillar network is mildly disorganized in some fibers. On Congo red (C), amyloid is deposited in the area surrounding muscle fibers. Scale bars: 100 μm
Figure 2
Figure 2
Leg muscle imaging. Computerized tomography (CT) (A), T2‐weighted short‐tau inversion recovery magnetic resonance imaging (MRI) (B). CT and MRI scans did not show any abnormalities
Figure 3
Figure 3
Clinical course from the diagnosis. The green arrow shows auto peripheral blood stem cell transplantation. The number in a colored block represents the number of cycles of chemotherapy. VRD, bortezomib, lenalidomide, and dexamethasone; HDCY, high‐dose cyclophosphamide; HDM, high‐dose melphalan; ELd, elotuzumab, lenalidomide, and dexamethasone; CK, creatine kinase; FLC, free light‐chain
See this image and copyright information in PMC

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