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. 2020 Jan-Mar;24(1):33-37.

Hidradenitis Suppurativa: a lesser-known cause of AA amyloidosis

Ö Helvacı  1 , G Güz  2 , E Adışen  3 , S K Cevher  4 , G Güz  5
Affiliations

Hidradenitis Suppurativa: a lesser-known cause of AA amyloidosis

Ö Helvacı et al. Hippokratia. 2020 Jan-Mar.

Abstract

Background: Hidradenitis suppurativa (HS) is a chronic, disabling skin disease. The estimated prevalence is 1-4 % worldwide. HS is a systemic inflammatory disease and can cause AA amyloidosis. The first report of HS-related amyloidosis dates back to 1966; since then, sporadic cases have been reported. Our work will be the first case series on HS and AA amyloidosis.

Case series: We report eight HS cases complicated with amyloidosis. Six patients were male. The median age was 44 years, and the median disease duration before the amyloidosis diagnosis was 15.5 years. In a mean follow-up of 18 ± 6 months, we achieved favorable renal responses in four of the eight cases (50 %). All cases had a dermatologic response, with four complete and four partial remissions.

Conclusion: HS is a systemic inflammatory disorder that may cause AA amyloidosis. Aggressive treatment of HS may halt the progression of amyloidosis. HIPPOKRATIA 2020, 24(1): 33-37.

Keywords: AA amyloidosis; Hidradenitis suppurativa; amyloidosis; end-stage renal disease.

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Conflict of interest statement

Authors reveal no conflicts of interest.

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