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. 2020 Dec 15;7(6):567-575.
doi: 10.1093/rb/rbaa031. eCollection 2020 Dec.

Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors

Chong Gao  1 , Zhi-Ye Qiu  2   3 , Jian-Wen Hou  1 , Wei Tian  1 , Jian-Ming Kou  1 , Xi Wang  1
Affiliations

Clinical observation of mineralized collagen bone grafting after curettage of benign bone tumors

Chong Gao et al. Regen Biomater. .

Abstract

Curettage of benign bone tumor is a common cause for bone defect. For such bone defect repair, autogenous bone, allogeneic bone and traditional artificial bone graft substitutes have many disadvantages. In recent years, a biomimetic mineralized collagen (MC) with similar composition and microstructures to the natural bone matrix was developed and used for treating various bone defects. In this work, a retrospective study analyzed clinical outcomes of patients treated with curettage of benign bone tumors and bone grafting with MC, in comparison to another group treated with the same surgical method and autogenous bone. Lane-Sandhu X-ray score of the autogenous bone group was superior to the MC group at 1 month after the operation, but the two groups had no statistical difference at 6 and 12 months. The MC group was better in Musculoskeletal Tumor Society scoring at 1 and 6 months after the operation, and the two groups had no statistical difference at 12 month. Therefore, the MC performed not as good as autogenous bone in early stage of bone healing but achieved comparable outcomes in long-term follow-ups. Moreover, the MC has advantages in function recovery and avoided potential complications induced by harvesting autogenous bone.

Keywords: autogenous bone; benign bone tumor; bone grafting; mineralized collagen.

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Figures

Figure 1.
Figure 1.
XRD pattern of the commercialized MC bone graft material.
Figure 2.
Figure 2.
Lane–Sandhu X-ray scores of clinical outcomes in this study at (A) 1 month, (B) 6 months and (C) 12 months after the operation.
Figure 3.
Figure 3.
Preoperative imageological examinations of the patient. An oval shadow was located at distal of femur on frontal (A) and lateral (B) views of plain radiography; evident cavity was shown on coronal (C) and sagittal (D) CT images; an obvious pathological fracture could be observed on 3D reconstruction of CT (E). (the lesion is noted by dashed circle in each picture).
Figure 4.
Figure 4.
Frontal (A) and lateral (B) views of plain radiography at 3 days after the operation (the surgical site is noted by dashed circle in each picture).
Figure 5.
Figure 5.
Frontal (A) and lateral (B) views of plain radiography at 1 month after the operation (the surgical site is noted by dashed circle in each picture).
Figure 6.
Figure 6.
Frontal (A) and lateral (B) views of plain radiography at 6 months after the operation (the surgical site is noted by dashed circle in each picture).
Figure 7.
Figure 7.
Plain radiography before (A) and after (B, frontal view; C, lateral view) removal of the internal fixation at 9 months after the operation (the surgical site is noted by dashed circle in each picture).
Figure 8.
Figure 8.
Frontal (A) and lateral (B) views of plain radiography at 12 months after the operation (the surgical site is noted by dashed circle in each picture).
Figure 9.
Figure 9.
Frontal (A) and lateral (B) views of the recovered surgical site of the patient at 12 months after the operation.
Figure 10.
Figure 10.
Preoperative imageological examinations of distal femoral space-occupying lesion of the 45-year-old female patient (A, frontal view of plain radiography; B, lateral view of plain radiography; C, coronal MRI; D, sagittal MRI; the lesion is noted by dashed circle in each picture).
Figure 11.
Figure 11.
Immediate frontal (A) and lateral (B) views of plain radiography after the operation (the surgical site is noted by dashed circle in each picture).
Figure 12.
Figure 12.
Frontal (A) and lateral (B) views of plain radiography at 6 months after the operation (the surgical site is noted by dashed circle in each picture).
Figure 13.
Figure 13.
Frontal (A) and lateral (B) views of plain radiography at 12 months after the operation (the surgical site is noted by dashed circle in each picture).
Figure 14.
Figure 14.
Frontal (A) and lateral (B) views of plain radiography at 24 months after the operation (the surgical site is noted by dashed circle in each picture).
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