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. 2020 Dec 7:10:608333.
doi: 10.3389/fonc.2020.608333. eCollection 2020.

Postoperative Adjuvant Chemotherapy Improved the Prognosis in Locally Advanced Cervical Cancer Patients With Optimal Response to Neoadjuvant Chemotherapy

Xiaojie Feng  1 , Hongmin Chen  1 , Lei Li  1 , Ling Gao  1 , Li Wang  1 , Xupeng Bai  2   3
Affiliations

Postoperative Adjuvant Chemotherapy Improved the Prognosis in Locally Advanced Cervical Cancer Patients With Optimal Response to Neoadjuvant Chemotherapy

Xiaojie Feng et al. Front Oncol. .

Abstract

Background: Few studies investigated the effectiveness of adjuvant chemotherapy (ACT) in patients with optimal response to neoadjuvant chemotherapy (NACT), and an optimal number of treatment cycles for these patients remains unknown.

Methods: A total of 261 Chinese patients with FIGO stage IB2-IIB cervical cancer who obtained an optimal response to NACT were included after radical surgery, and the disease-free survival (DFS) and overall survival (OS) of these patients treated with different cycles of postoperative ACT were compared using the Log-rank test and multivariate analysis.

Results: We found that the prognosis of optimal responders treated with postoperative ACT was significantly better than those without further adjuvant therapy. The multivariate analysis showed that postoperative ACT was an independent prognostic factor for DFS. However, there was no significant difference in the DFS and OS between patients who had three cycles of ACT and those with six cycles. Further analysis revealed a significant association of six cycles of ACT with the risk of leukopenia, nausea/vomiting, and rash.

Conclusion: Our data suggest that additional three cycles of ACT after surgery may improve the clinical outcome of optimal responders in terms of DFS, OS, and drug toxicity.

Keywords: cervical cancer; neoadjuvant chemotherapy; optimal response; survival; toxicity.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
(A) Disease-free survival (DFS) and (B) overall survival (OS) by postoperative treatment. Differences in DFS and OS by treatment were evaluated using the Log-rank test. P < 0.05 was statistically significant.
Figure 2
Figure 2
(A) Disease-free survival (DFS) and (B) overall survival (OS) by the cycle number of postoperative adjuvant chemotherapy. Differences in DFS and OS by treatment were evaluated using the Log-rank test.
See this image and copyright information in PMC

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References

    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin (2015) 65(2):87–108. 10.3322/caac.21262 - DOI - PubMed
    1. Arbyn M, Castellsague X, de Sanjose S, Bruni L, Saraiya M, Bray F, et al. Worldwide burden of cervical cancer in 2008. Ann Oncol (2011) 22(12):2675–86. 10.1093/annonc/mdr015 - DOI - PubMed
    1. Benedetti-Panici P, Greggi S, Colombo A, Amoroso M, Smaniotto D, Giannarelli D, et al. Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study. J Clin Oncol (2002) 20(1):179–88. 10.1200/JCO.2002.20.1.179 - DOI - PubMed
    1. Gadducci A, Sartori E, Maggino T, Zola P, Cosio S, Zizioli V, et al. Pathological response on surgical samples is an independent prognostic variable for patients with Stage Ib2-IIb cervical cancer treated with neoadjuvant chemotherapy and radical hysterectomy: an Italian multicenter retrospective study (CTF Study). Gynecol Oncol (2013) 131(3):640–4. 10.1016/j.ygyno.2013.09.029 - DOI - PubMed
    1. Buda A, Lissoni AA, Floriani I, Biagioli E, Gerardi C, Bonazzi C, et al. Long-Term Clinical Benefits of Neoadjuvant Chemotherapy in Women With Locally Advanced Cervical Cancer: Validity of Pathological Response as Surrogate Endpoint of Survival. Int J Gynecol Cancer (2015) 25(8):1468–75. 10.1097/IGC.0000000000000515 - DOI - PubMed

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