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. 2020 Nov;495(1):289-291.
doi: 10.1134/S1607672920060010. Epub 2020 Dec 25.

Influence of HLDF Differentiation Factor on Nonspecific Invasive Breast Carcinoma in vitro

A I Autenshlyus  1   2 , I P Zhurakovsky  3   4 , K I Davletova  3   4 , A P Bogachuk  5 , V V Lyakhovich  4 , V M Lipkin  5
Affiliations

Influence of HLDF Differentiation Factor on Nonspecific Invasive Breast Carcinoma in vitro

A I Autenshlyus et al. Dokl Biochem Biophys. 2020 Nov.

Abstract

The study was carried out on samples of invasive breast carcinoma of no special type from 36 patients aged 48.0 to 62.8 years. The effect of HLDF on nonspecific invasive breast carcinoma was a decrease in the relative content of low-differentiated cells and an increase in the relative content of highly differentiated cells. HLDF did not have a cytotoxic effect leading to the death of low-differentiated cells but promoted promotes the acquisition of a higher degree of differentiation by them. A more pronounced effect of HLDF was observed in more aggressive metastasizing forms of neoplasia, which allows us to consider this differentiation factor as a candidate for use in the differentiation therapy of malignant neoplasms.

Keywords: HLDF; differentiation therapy; human leukemia differentiation factor; invasive breast carcinoma of no special type.

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References

REFERENCES

    1. Kostanyan, I.A., Astapova, M.V., Starovoytova, E.V., et al., A new human leukemia cell 8.2 kDa differentiation factor: isolation and primary structure, FEBS Lett., 1994, vol. 356, nos. 2–3, pp. 327–329. https://doi.org/10.1016/0014-5793(94)01306-3 - DOI - PubMed
    1. Kostanyan, I.A., Astapova, M.V., Starovoitova, E.V., et al., A new differentiation factor from the culture medium of HL-60 cells treated with retinoic acid. Isolation and determination of the primary structure, Bioorg. Khim., 1995, vol. 21, pp. 243–248.
    1. Sosnina, A.V., Morozov, D.V., Varaksin, N.A., et al., Human leukemia differentiation factor (HLDF) controls the cytokine-producing function of blood cells in gastric adenocarcinomas, Dokl. Biol. Sci., 2014, vol. 454, pp. 72–74. https://doi.org/10.1134/S0012496614010207 - DOI - PubMed
    1. Kovyazin, V.A., Shchelokova, E.E., Kostanyan, I.A., et al., Proapoptotic factor HLDF in normal, hyperplastic, and tumor endometrium, Arkh. Patol., 2007, vol. 69, no. 3, pp. 23–26.
    1. Sosnina, A.V., Mikhailova, E.S., Autenshlyus, A.I., et al., Classes and subclasses of antibodies to the differentiation factor HLDF and haponin peptides, the relationship between their level and pathological parameters of colon adenocarcinomas, Immunologiya, 2012, vol. 33, no. 2, pp. 92–94.

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