Abstract

PIP: 41 women under 30 years of age took part in a prospective, double-blind study to determine whether indomethacin is effective in treating dysmenorrhea. Indomethacin capsules (35 mg x 3/day) or suppositories (100 mg) or placebos were administered for 2 consecutive days in 2 consecutive menstrual cycles, after which the other type of preparation (indomethacin or placebo) was used. 13 said that indomethacin and placebo use were equally effective in relieving dysmenorrhea. 28 preferred indomethicin (P .00025). Days of sick leave and days of bed rest (P .0005), use of thermotherapy (P .0025), and duration of uterine cramping and use of supplemental medicine (P .00025) were all significantly reduced among indomethicin users. Gastrointestinal symptoms were significantly more frequent among indomethicin users (P .05).