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Case Reports
. 2022 Jan 1;44(1):e237-e240.
doi: 10.1097/MPH.0000000000002036.

Diagnostic Considerations in H1N1 Influenza-induced Thrombotic Microangiopathy

Anthony Sabulski  1   2 , Edward J Nehus  1   3 , Sonata Jodele  1   2 , Kiersten Ricci  1   2
Affiliations
Case Reports

Diagnostic Considerations in H1N1 Influenza-induced Thrombotic Microangiopathy

Anthony Sabulski et al. J Pediatr Hematol Oncol. .

Abstract

Influenza virus can trigger atypical hemolytic uremic syndrome and present with complement-driven thrombotic microangiopathy (TMA). When administered promptly, complement-blocking therapies can spare organ injury and be lifesaving. However, diagnosing TMA in the setting of a severe viral infection can be challenging, as a significant overlap of symptoms and disease complications exists. This is particularly true in influenza virus infections and more recently, Coronavirus disease 2019 (COVID-19) infections. We present a 16-year-old male with H1N1 influenza-induced atypical hemolytic uremic syndrome who quickly improved with complement-blocking therapy, highlighting an urgent need to include TMA in the differential diagnosis of severe viral infections.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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