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. 2021 Sep;42(9):1124-1127.
doi: 10.1017/ice.2020.1361. Epub 2020 Dec 29.

A multi-institutional outbreak of New Delhi metallo-β-lactamase-producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene

Ester Solter  1 , Jason C Kwong  2   3 , Aaron Walton  1   4 , Norelle Sherry  2   3 , Benjamin P Howden  2   3 , M Lindsay Grayson  3   5 , David Schwartz  1 , Elizabeth Temkin  1 , Sammy Frenk  1 , Yehuda Carmeli  1   6 , Mitchell J Schwaber  1   6
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A multi-institutional outbreak of New Delhi metallo-β-lactamase-producing Escherichia coli with subsequent acquisition of the Klebsiella pneumoniae carbapenemase gene

Ester Solter et al. Infect Control Hosp Epidemiol. 2021 Sep.

Abstract

We characterized 57 isolates from a 2-phase clonal outbreak of New Delhi metallo-β-lactamase-producing Eschericha coli, involving 9 Israeli hospitals; all but 1 isolate belonged to sequence-type (ST) 410. Most isolates in the second phase harbored blaKPC-2 in addition to blaNDM-5. Genetic sequencing revealed most dual-carbapenemase-producing isolates to be monophyletically derived from a common ancestor.

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