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Review
. 2021 Jan 1;29(1):31-40.
doi: 10.4062/biomolther.2020.215.

Cell Autonomous Circadian Systems and Their Relation to Inflammation

Venkata Prakash Annamneedi  1 , Jun Woo Park  1 , Geum Seon Lee  2 , Tae Jin Kang  1
Affiliations
Review

Cell Autonomous Circadian Systems and Their Relation to Inflammation

Venkata Prakash Annamneedi et al. Biomol Ther (Seoul). .

Abstract

All living beings on earth have an important mechanism of 24-h periodicity, which controls their physiology, metabolism, and behavior. In humans, 24-h periodicity is regulated by the superchiasmatic nucleus (SCN) through external and environmental cues. Peripheral organs demonstrate circadian rhythms and circadian clock functions, and these are also observed in cultured cell lines. Every cell contains a CLOCK: BMAL1 loop for the generation of circadian rhythms. In this review, we focused on cell autonomous circadian rhythms in immune cells, the inflammatory diseases caused by disruption of circadian rhythms in hormones, and the role of clock genes in inflammatory diseases.

Keywords: Asthma; Atopic dermatitis; BMAL 1; Circadian rhythm; PER2.

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Conflict of interest statement

CONFLICT OF INTEREST

The authors confirm that they have no conflicts of interest.

Figures

Fig. 1
Fig. 1
Schematic for the complex network of the central nervous system, superchiasmatic nucleus (SCN), peripheral endocrine system, and immune system.
Fig. 2
Fig. 2
Coordination of environmental cues and peripheral organs by the superchiasmatic nucleus (SCN) through downstream signals.
Fig. 3
Fig. 3
The cell autonomous transcription-translation oscillator loop (Figure modified from Robinson and Reddy, 2014).
See this image and copyright information in PMC

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