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. 2021 Jan 5;101(1):adv00368.
doi: 10.2340/00015555-3739.

Are Infants and Toddlers with Moderate-to-severe Atopic Dermatitis Undertreated? Experiences of a Finnish Tertiary Care Hospital

Andreas Antti  1 , Alexander Salava, Miia Perälä, Anna S Pelkonen, Mika J Mäkelä, Anita Remitz
Affiliations

Are Infants and Toddlers with Moderate-to-severe Atopic Dermatitis Undertreated? Experiences of a Finnish Tertiary Care Hospital

Andreas Antti et al. Acta Derm Venereol. .
No abstract available

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Comparison of treatment groups. (a) Switch to more potent treatment. (b) Group characteristics at baseline; T1=0.03% tacrolimus ointment only; T2=0.03% and 0.1% tacrolimus ointment; C1: hydrocortisone 1% cream only; C2: hydrocortisone and hydrocortisone-17-butyrate-cream.
Fig. 2
Fig. 2
Comparison of group characteristics at baseline. (a) Eczema Area and Severity Index (EASI) score. (b) Blood eosinophil count (aReference values for blood eosinophil count: 1 month – 1 year: 0.2–1.7 E9/l; 2–4 years: 0–0.30 E9/l). (c) Total serum IgE (bReference values for total serum IgE: 6 months–1 year 0–70 kU/l; 2–3 years 0–110 kU/l; 4–7 years 0–130 kU/l). (d) Signs of early IgE-mediated sensitization (cElevated serum total IgE and/ or elevated specific IgEs to aeroallergens or food allergens and/or positive skin-prick tests); mild treatment: hydrocortisone 1% cream or tacrolimus 0.03% ointment only; Switch to more potent treatment: 0.03% and 0.1% tacrolimus ointment or hydrocortisone and hydrocortisone-17-butyrate-cream.
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References

    1. LePoidevin LM, Lee DE, Shi VY. A comparison of international management guidelines for atopic dermatitis. Pediatr Dermatol 2019; 36: 36–65. - PubMed
    1. Wollenberg A, Barbarot S, Bieber T, Christen-Zaech S, Deleuran M, Fink-Wagner A, et al. . Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol 2018; 32: 657–682. - PubMed
    1. Siegfried EC, Jaworski JC, Kaiser JD, Hebert AA. Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis. BMC Pediatr 2016; 16: 75. - PMC - PubMed
    1. Perälä M, Ahola M, Mikkola T, Pelkonen AS, Remitz A, Mäkelä MJ. Young children with moderate-to-severe atopic dermatitis can be treated safely and effectively with either topical tacrolimus or mild corticosteroids. Acta Paediatr 2020; 109: 550–556. - PubMed
    1. Mandelin JM, Rubins A, Remitz A, Cirule K, Dickinson J, Ho V, et al. . Long-term efficacy and tolerability of tacrolimus 0.03% ointment in infants: a two-year open-label study. Int J Dermatol 2012; 51: 104–110. - PubMed

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