Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Mar:145:111220.
doi: 10.1016/j.exger.2020.111220. Epub 2020 Dec 26.

Vascular dysfunction as a potential culprit of sarcopenia

Yun Kyung Jeon  1 , Myung Jun Shin  2 , Sunil Kumar Saini  3 , Carlo Custodero  4 , Monica Aggarwal  5 , Stephen D Anton  3 , Christiaan Leeuwenburgh  3 , Robert T Mankowski  6
Affiliations
Review

Vascular dysfunction as a potential culprit of sarcopenia

Yun Kyung Jeon et al. Exp Gerontol. 2021 Mar.

Abstract

Aging-related changes to biological structures such as cardiovascular and musculoskeletal systems contribute to the development of comorbid conditions including cardiovascular disease and frailty, and ultimately lead to premature death. Although, frail older adults often demonstrate both cardiovascular and musculoskeletal comorbidities, the etiology of sarcopenia, and especially the contribution of cardiovascular aging is unclear. Aging-related vascular calcification is prevalent in older adults and is a known risk factor for cardiovascular disease and death. The effect vascular calcification has on function during aging is not well understood. Emerging findings suggest vascular calcification can impact skeletal muscle perfusion, negatively affecting nutrient and oxygen delivery to skeletal muscle, ultimately accelerating muscle loss and functional decline. The present review summarizes existing evidence on the biological mechanisms linking vascular calcification with sarcopenia during aging.

Keywords: Aging; Biology of aging; Inflammation; Oxidative stress; Skeletal muscle.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. Schematic interaction between Vascular calcification and Muscular Atrophy
NO: nitric oxide, VEGF: vascular endothelial growth factor, ROS: reactive oxygen species, TNF-α: Tumor necrosis factor, IL-6: interleukin-6; GH: growth hormone.
See this image and copyright information in PMC

References

    1. Mathers CD, Stevens GA, Boerma T, White RA, Tobias MI. Causes of international increases in older age life expectancy. The Lancet. 2015;385(9967):540–548. - PubMed
    1. Fried LP, Tangen CM, Walston J, et al. Frailty in older adults: evidence for a phenotype. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 2001;56(3):M146–M157. - PubMed
    1. Ofori-Asenso R, Chin KL, Mazidi M, et al. Global incidence of frailty and prefrailty among community-dwelling older adults: a systematic review and meta-analysis. JAMA network open. 2019;2(8):e198398–e198398. - PMC - PubMed
    1. Vellas B, Fielding R, Bens C, et al. Implications of ICD-10 for sarcopenia clinical practice and clinical trials: report by the International Conference on Frailty and Sarcopenia Research Task Force. The Journal of frailty & aging. 2018;7(1):2–9. - PubMed
    1. von Haehling S, Morley JE, Anker SD. An overview of sarcopenia: facts and numbers on prevalence and clinical impact. Journal of cachexia, sarcopenia and muscle. 2010;1(2):129–133. - PMC - PubMed

Publication types

LinkOut - more resources