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. 2020 Dec 23;13(1):22.
doi: 10.3390/cancers13010022.

Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy

Christina Schröder  1   2   3 , André Buchali  1 , Paul Windisch  2 , Erwin Vu  4 , Lucas Basler  3 , Daniel R Zwahlen  2   5 , Robert Förster  2   5
Affiliations

Impact of Low-Dose Irradiation of the Lung and Heart on Toxicity and Pulmonary Function Parameters after Thoracic Radiotherapy

Christina Schröder et al. Cancers (Basel). .

Abstract

Objective: To assess the impact of (low) dose irradiation to the lungs and heart on the incidence of pneumonitis and pulmonary function changes after thoracic radiotherapy (RT). Methods/Material: Data of 62 patients treated with curative thoracic radiotherapy were analyzed. Toxicity data and pulmonary function tests (PFTs) were obtained before RT and at 6 weeks, at 12 weeks, and at 6 months after RT. PFTs included ventilation (e.g., vital capacity) and diffusion parameters (e.g., diffusion capacity for carbon monoxide (DLCO)). Dosimetric data of the lung and heart were extracted to assess the impact of dose on PFT changes and radiation pneumonitis (RP).

Results: No statistically significant correlations between dose parameters and changes in ventilation parameters were found. There were statistically significant correlations between DLCO and low-dose parameters of the lungs (V5Gy-V30Gy (%)) and irradiation of the heart during the follow-up up to 6 months after RT, as well as a temporary correlation of the V60Gy (%) on the blood gas parameters at 12 weeks after RT. On multivariate analysis, both heart and lung parameters had a significant impact on DLCO. There was no statistically significant influence of any patient or treatment-related (including dose parameters) factors on the incidence of ≥G2 pneumonitis.

Conclusion: There seems to be a lasting impact of low dose irradiation to the lung as well as irradiation to the heart on the DLCO after thoracic radiotherapy. No influence on RP was found in this analysis.

Keywords: lung neoplasms; organs at risk; radiation injuries; respiratory function tests.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

    1. Borst G.R., De Jaeger K., Belderbos J., Burgers S.A., Lebesque J.V. Pulmonary function changes after radiotherapy in non–small-cell lung cancer patients with long-term disease-free survival. Int. J. Radiat. Oncol. Biol. Phys. 2005;62:639–644. doi: 10.1016/j.ijrobp.2004.11.029. - DOI - PubMed
    1. Abratt R.P., Willcox P.A. The effect of irradiation on lung function and perfusion in patients with lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 1995;31:915–919. doi: 10.1016/0360-3016(94)00513-3. - DOI - PubMed
    1. Miller K.L., Zhou S.-M., Barrier R.C., Jr., Shafman T., Folz R.J., Clough R.W., Marks L.B. Long-term changes in pulmonary function tests after definitive radiotherapy for lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 2003;56:611–615. doi: 10.1016/S0360-3016(03)00182-2. - DOI - PubMed
    1. Stanic S., Paulus R., Timmerman R.D., Michalski J.M., Barriger R.B., Bezjak A., Videtic G.M.M., Bradley J. No clinically significant changes in pulmonary function following stereotactic body radiation therapy for early- stage peripheral non-small cell lung cancer: An analysis of RTOG 0236. Int. J. Radiat. Oncol. Biol. Phys. 2014;88:1092–1099. doi: 10.1016/j.ijrobp.2013.12.050. - DOI - PMC - PubMed
    1. Jaen J., Vazquez G., Alonso E., De las Penas M., Diaz L., De las Heras M., Perez-Regadera J. Long-term Changes in Pulmonary Function After Incidental Lung Irradiation for Breast Cancer: A Prospective Study With 7-Year Follow-up. Int. J. Radiat. Oncol. Biol. Phys. 2012;84:e565–e570. doi: 10.1016/j.ijrobp.2012.07.003. - DOI - PubMed

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