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. 2020 Dec 23;10(1):14.
doi: 10.3390/jcm10010014.

Alteration within the Hippocampal Volume in Patients with LHON Disease-7 Tesla MRI Study

Cezary Grochowski  1 , Kamil Jonak  2   3 , Marcin Maciejewski  4 , Andrzej Stępniewski  5 , Mansur Rahnama-Hezavah  6
Affiliations

Alteration within the Hippocampal Volume in Patients with LHON Disease-7 Tesla MRI Study

Cezary Grochowski et al. J Clin Med. .

Abstract

Purpose: The aim of this study was to assess the volumetry of the hippocampus in the Leber's hereditary optic neuropathy (LHON) of blind patients.

Methods: A total of 25 patients with LHON were randomly included into the study from the national health database. A total of 15 patients were selected according to the inclusion criteria. The submillimeter segmentation of the hippocampus was based on three-dimensional spoiled gradient recalled acquisition in steady state (3D-SPGR) BRAVO 7T magnetic resonance imaging (MRI) protocol.

Results: Statistical analysis revealed that compared to healthy controls (HC), LHON subjects had multiple significant differences only in the right hippocampus, including a significantly higher volume of hippocampal tail (p = 0.009), subiculum body (p = 0.018), CA1 body (p = 0.002), hippocampal fissure (p = 0.046), molecular layer hippocampus (HP) body (p = 0.014), CA3 body (p = 0.006), Granule Cell (GC) and Molecular Layer (ML) of the Dentate Gyrus (DG)-GC ML DG body (p = 0.003), CA4 body (p = 0.001), whole hippocampal body (p = 0.018), and the whole hippocampus volume (p = 0.023).

Discussion: The ultra-high-field magnetic resonance imaging allowed hippocampus quality visualization and analysis, serving as a powerful in vivo diagnostic tool in the diagnostic process and LHON disease course assessment. The study confirmed previous reports regarding volumetry of hippocampus in blind individuals.

Keywords: 7 Tesla; LHON; Leber; blindness; hippocampus.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Hippocampal segmentation. T1 images of hippocampal subfields in the sagittal (A) and coronal (B) planes.
Figure 2
Figure 2
Correlation between duration of illness and (A) the volume of hippocampal fissure and (B) the volume of fimbria in the LHON patients. “°”—refers to LHON participants results; solid red line—trend line; dashed lines—confidence interval.
See this image and copyright information in PMC

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