Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Dec 23;10(1):14.
doi: 10.3390/jcm10010014.

Alteration within the Hippocampal Volume in Patients with LHON Disease-7 Tesla MRI Study

Cezary Grochowski  1 , Kamil Jonak  2   3 , Marcin Maciejewski  4 , Andrzej Stępniewski  5 , Mansur Rahnama-Hezavah  6
Affiliations

Alteration within the Hippocampal Volume in Patients with LHON Disease-7 Tesla MRI Study

Cezary Grochowski et al. J Clin Med. .

Abstract

Purpose: The aim of this study was to assess the volumetry of the hippocampus in the Leber's hereditary optic neuropathy (LHON) of blind patients.

Methods: A total of 25 patients with LHON were randomly included into the study from the national health database. A total of 15 patients were selected according to the inclusion criteria. The submillimeter segmentation of the hippocampus was based on three-dimensional spoiled gradient recalled acquisition in steady state (3D-SPGR) BRAVO 7T magnetic resonance imaging (MRI) protocol.

Results: Statistical analysis revealed that compared to healthy controls (HC), LHON subjects had multiple significant differences only in the right hippocampus, including a significantly higher volume of hippocampal tail (p = 0.009), subiculum body (p = 0.018), CA1 body (p = 0.002), hippocampal fissure (p = 0.046), molecular layer hippocampus (HP) body (p = 0.014), CA3 body (p = 0.006), Granule Cell (GC) and Molecular Layer (ML) of the Dentate Gyrus (DG)-GC ML DG body (p = 0.003), CA4 body (p = 0.001), whole hippocampal body (p = 0.018), and the whole hippocampus volume (p = 0.023).

Discussion: The ultra-high-field magnetic resonance imaging allowed hippocampus quality visualization and analysis, serving as a powerful in vivo diagnostic tool in the diagnostic process and LHON disease course assessment. The study confirmed previous reports regarding volumetry of hippocampus in blind individuals.

Keywords: 7 Tesla; LHON; Leber; blindness; hippocampus.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Hippocampal segmentation. T1 images of hippocampal subfields in the sagittal (A) and coronal (B) planes.
Figure 2
Figure 2
Correlation between duration of illness and (A) the volume of hippocampal fissure and (B) the volume of fimbria in the LHON patients. “°”—refers to LHON participants results; solid red line—trend line; dashed lines—confidence interval.
See this image and copyright information in PMC

References

    1. Carelli V. Leber’s hereditary optic neuropathy. In: Schapira A.H.V., DiMauro S., editors. Mitochondrial Disorders in Neurology: Blue Books of Practical Neurology. 2nd ed. Volume 26 Butterworth-Heinemann; Boston, MA, USA: 2002.
    1. Fantini M., Asanad S., Karanjia R., Sadun A. Hormone replacement therapy in Leber’s hereditary optic neuropathy: Accelerated visual recovery in vivo. J. Curr. Ophthalmol. 2019;31:102–105. doi: 10.1016/j.joco.2018.10.003. - DOI - PMC - PubMed
    1. Hudson G., Carelli V., Horvath R., Zeviani M., Smeets H.J., Chinnery P.F. X-Inactivation patterns in females harboring mtDNA mutations that cause Leber hereditary optic neuropathy. Mol. Vis. 2007;13:18199976. - PubMed
    1. Summerfield J.J., Lepsien J., Gitelman D.R., Mesulam M.M., Nobre A.C. Orienting Attention Based on Long-Term Memory Experience. Neuron. 2006;49:905–916. doi: 10.1016/j.neuron.2006.01.021. - DOI - PubMed
    1. Rolls E.T., Xiang J.Z. Spatial view cells in the primate hippocampus andmemory recall. Rev. Neurosci. 2006;17:175–200. - PubMed