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. 2020 Dec 7:2020:9283651.
doi: 10.1155/2020/9283651. eCollection 2020.

Higher Serum-Soluble α-Klotho Level Does Not Predict Longer Survival after Stroke

Dagmara Adamska-Tomaszewska  1 , Jarosław Wajda  2 , Katarzyna Wyskida  3 , Dawid Bednarczyk  4 , Maciej Świat  5   6 , Aleksander J Owczarek  7 , Monika Puzianowska-Kuźnicka  8   9 , Magdalena Olszanecka-Glinianowicz  3 , Jerzy Chudek  10   11
Affiliations

Higher Serum-Soluble α-Klotho Level Does Not Predict Longer Survival after Stroke

Dagmara Adamska-Tomaszewska et al. Biomed Res Int. .

Abstract

Results: There were 5 recurrent strokes and 89 deaths during the 36-month follow-up. Even though no significant differences in OS and SFS between soluble α-Klotho level tertile groups were recorded, unexpectedly, OS and SFS were highest in patients with the lowest soluble α-Klotho concentrations. Moreover, the Cox proportional models adjusted for established risk factors, kidney function, and the severity of stroke revealed that each 100 pg/mL increase in soluble α-Klotho levels was associated with decreased OS (HR = 0.951 (0.908-0.995), p < 0.05) and SFS (HR = 0.949 (0.908-0.993), p < 0.05). In addition, the α-Klotho to iFGF23 index was predicting neither OS nor SFS.

Conclusion: Soluble α-Klotho levels in serum were not related to the severity of neurological deficits and long-term outcomes in patients with IS. No neuroprotective effect of soluble α-Klotho levels in patients with IS was demonstrated.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The severity of stroke according to NIHSS-I score in serum-soluble α-Klotho level tertiles.
Figure 2
Figure 2
Overall survival (OS) in serum-soluble α-Klotho level tertiles (Kaplan-Meier plot).
Figure 3
Figure 3
Stroke-free survival (SFS) in serum-soluble α-Klotho level tertiles (Kaplan-Meier plot).
See this image and copyright information in PMC

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