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. 1988 Jan 15;150(1):412-8.
doi: 10.1016/0006-291x(88)90536-0.

Expression of epidermal growth factor receptor proto-oncogene mRNA in regenerating rat liver

A C Johnson  1 , S H Garfield, G T Merlino, I Pastan
Affiliations

Expression of epidermal growth factor receptor proto-oncogene mRNA in regenerating rat liver

A C Johnson et al. Biochem Biophys Res Commun. .

Abstract

The expression of EGF receptor mRNAs in regenerating rat liver was measured using two nonoverlapping cDNA probes for the human gene from a highly conserved region. These probes (pE7 and pE62) both hybridized to RNA species of 10 and 6 kb. The 10 and 6 kb RNA species were shown to decrease in the first 12 hours after partial hepatectomy. However, significant increases above control levels were noted at 24h and 72h. The level of alpha-actin mRNA increased as has been previously reported. These results suggest that a transcriptional and/or a posttranscriptional regulatory mechanism exists in regenerating rat liver with respect to EGF receptor gene expression.

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