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Review
. 2021 Mar;23(3):496-503.
doi: 10.1111/jch.14163. Epub 2020 Dec 30.

Long sleep duration and cardiovascular disease: Associations with arterial stiffness and blood pressure variability

Hideaki Matsubayashi  1 , Michiaki Nagai  1 , Keigo Dote  1 , Yuda Turana  2 , Saulat Siddique  3 , Yook-Chin Chia  4   5 , Chen-Huan Chen  6   7   8 , Hao-Min Cheng  6   7   8   9 , Huynh Van Minh  10 , Narsingh Verma  11 , Jam Chin Tay  12 , Boon Wee Teo  13 , Kazuomi Kario  14
Affiliations
Review

Long sleep duration and cardiovascular disease: Associations with arterial stiffness and blood pressure variability

Hideaki Matsubayashi et al. J Clin Hypertens (Greenwich). 2021 Mar.

Abstract

Although short and long sleep duration are both risk factors of cardiovascular disease (CVD), the recent meta-analyses have been shown that long sleep duration was closely associated with CVD mortality. While the specific mechanism underlying the association between long sleep duration and CVD remains unclear, long sleep duration was shown to be associated with arterial stiffness and blood pressure variability (BPV) in many Asian populations. This review article will focus on the pathophysiology of long sleep duration, arterial stiffness, BPV and their effects on CVD. To set the stage for this review, we first summarize the current insights for the relationship between long sleep duration and CVD in relation to arterial stiffness and BPV.

Keywords: arterial stiffness; blood pressure variability; cardiovascular disease; sleep duration.

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Conflict of interest statement

YC Chia has received honorarium and sponsorship to attend conferences and seminars from Boeringher‐Ingelheim, Pfizer, Omron, Servier and Xepa‐Sol and an investigator‐initiated research grant from Pfizer and Omron. CH Chen reports personal fees from Novartis, Sanofi, Daiichi Sankyo, SERVIER, Bayer, and Boehringer Ingelheim Pharmaceuticals, Inc HM Cheng received speakers honorarium and sponsorship to attend conferences and CME seminars from Eli Lilly and AstraZeneca; Pfizer Inc; Bayer AG; Boehringer Ingelheim Pharmaceuticals, Inc; Daiichi Sankyo, Novartis Pharmaceuticals, Inc; SERVIER; Co., Pharmaceuticals Corporation; Sanofi; TAKEDA Pharmaceuticals International; Menarini Co., Ltd.; and served as an advisor or consultant for ApoDx Technology, Inc K. Kario has received research grants from Omron Healthcare and A&D Co. The other authors have no conflict of interest to declare in relation to this article.

All of the authors declare no conflict of interest.

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