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Review
. 2021 Jun;46(3):206-211.
doi: 10.1007/s00059-020-05012-z. Epub 2020 Dec 30.

Heart and kidney disease: a cardiovascular high-risk constellation

Stefan J Schunk  1   2 , Thimoteus Speer  3   4 , Danilo Fliser  3
Affiliations
Review

Heart and kidney disease: a cardiovascular high-risk constellation

Stefan J Schunk et al. Herz. 2021 Jun.

Abstract
in English, German

Chronic kidney disease (CKD) is associated with substantial cardiovascular morbidity and mortality. This is mediated by highly prevalent traditional cardiovascular risk factors such as arterial hypertension and diabetes mellitus in patients with CKD, but also by the presence of CKD-specific so-called nontraditional cardiovascular risk factors such as vascular calcification, uremic toxins, uremic dyslipidemia, inflammation, and oxidative stress. Therefore, the primary and secondary prevention of cardiovascular disease represents an important part of the care of patients with CKD. This entails optimal control of blood pressure and diabetes, treatment of the uremic dyslipidemia, as well as life-style modifying factors such as weight reduction and smoking cessation.

Die chronische Nierenerkrankung ist mit einer erheblichen kardiovaskulären Morbidität und Mortalität assoziiert. Ursächlich hierfür ist zum einen die hohe Prävalenz traditioneller kardiovaskulärer Risikofaktoren wie arterielle Hypertonie und Diabetes mellitus bei Nierenkranken und zum anderen niereninsuffizienzspezifische, sog. nichttraditionelle kardiovaskuläre Risikofaktoren. Hierzu gehören vaskuläre Kalzifikation, Urämietoxine, die urämische Dyslipidämie sowie Inflammation und oxidativer Stress. Deshalb kommt der Primär- und Sekundärprävention kardiovaskulärer Erkrankungen in der Nephrologie eine zentrale Rolle zu. Hierzu gehören eine optimale Blutdruck- und Blutzuckereinstellung, die Therapie der urämischen Dyslipidämie sowie lebensstilmodifizierende Faktoren wie Gewichtsreduktion und Nikotinkarenz.

Keywords: Arterial hypertension; Diabetes mellitus; Dyslipidemia; Renal insufficiency, chronic; Risk factors.

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References

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