Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul;32(5):937-944.
doi: 10.1111/pai.13444. Epub 2021 Jan 11.

Association of serum periostin levels with clinical features in children with asthma

Süleyman Tolga Yavuz  1 , Soyhan Bagci  2 , Ahmet Bolat  3 , Onur Akin  3 , Rainer Ganschow  4
Affiliations

Association of serum periostin levels with clinical features in children with asthma

Süleyman Tolga Yavuz et al. Pediatr Allergy Immunol. 2021 Jul.

Abstract

Background: The aim of this study was to investigate the association of serum periostin levels with clinical features in children with asthma.

Methods: Children with physician-diagnosed asthma who attended regularly to an outpatient pediatric allergy and asthma center were enrolled in the study along with control subjects. Asthma severity and control status of the patients were evaluated according to the recent GINA guidelines.

Results: A total of 158 children (125 with asthma and 33 age- and sex-matched control subjects) with a median age of 10.2 years (range 5.9-17.0) were enrolled. Asthma severity was mild in 41 (32.8%), moderate in 63 (50.4%), and severe in 21 (16.8%) children. Children with asthma had significantly higher periostin levels than controls (53.1 ± 13.1 vs 43.0 ± 11.2 ng/mL, P < .001). The mean serum periostin levels in children with severe asthma (63.8 ± 10.8) were significantly higher than in children with moderate asthma (53.3 ± 12.7) and mild asthma (47.4 ± 11.1) (P < .001). Results of multivariable logistic regression analysis demonstrated an association between serum periostin levels and asthma severity in children (OR, 1.10; 95% CI, 1.04-1.15, P < .001). When analyzed for the best cut-off value with the highest combined sensitivity and specificity, a cut-off value of 52 ng/mL for serum periostin level was obtained with sensitivity, specificity, PPV, and NPV of 100%, 50%, 29%, and 100%, respectively.

Conclusion: Although serum periostin levels are higher in children with asthma, its diagnostic role in identifying children with severe asthma is limited.

Keywords: asthma; biomarker; children; periostin; severe asthma.

PubMed Disclaimer

References

REFERENCES

    1. Sanchez-Garcia S, Habernau Mena A, Quirce S. Biomarkers in inflammometry pediatric asthma: utility in daily clinical practice. Eur Clin Respir J. 2017;4:1356160.
    1. O'Dwyer DN, Moore BB. The role of periostin in lung fibrosis and airway remodeling. Cell Mol Life Sci. 2017;74:4305-4314.
    1. Matsumoto H. Role of serum periostin in the management of asthma and its comorbidities. Respir Investig. 2020;58:144-154.
    1. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention; 2018. www.ginasthma.org. Accessed December 20, 2020
    1. Sahiner UM, Civelek E, Yavuz ST, Buyuktiryaki AB, Tuncer A, Sekerel BE. Skin prick testing to aeroallergen extracts: what is the optimal panel in children and adolescents in Turkey? Int Arch Allergy Immunol. 2012;157:391-398.