Hydrogen sulfide therapy: a narrative overview of current research and possible therapeutic implications in future
- PMID: 33380586
- PMCID: PMC8092145
- DOI: 10.4103/2045-9912.304225
Hydrogen sulfide therapy: a narrative overview of current research and possible therapeutic implications in future
Abstract
Diabetic nephropathy is one of the most important comorbidities in the diabetic population. In China, more and more young patients are showing an increasing prevalence of diabetes. As a gas molecule, hydrogen sulfide (H2 S) has some unique chemical and physiological functions. In recent years, it has been studied in various fields. These effects are manifested in the induction of renal vasodilation and anti-renal vascular fibrosis. The ball clearing function is improved. Therefore, increasing prospective studies have focused on how H2 S protects diabetic nephropathy and how to obtain H2 S by modern means to treat diabetic nephropathy.
Keywords: clinical research; diabetic nephropathy; experimental research; future application; hydrogen sulfide; kidney; pathological mechanism; renal hypertension; renal protection.
Conflict of interest statement
None.
References
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- Jung KJ, Jang HS, Kim JI, Han SJ, Park JW, Park KM. Involvement of hydrogen sulfide and homocysteine transsulfuration pathway in the progression of kidney fibrosis after ureteral obstruction. Biochim Biophys Acta. 2013;1832:1989–1997. - PubMed
-
- Ding T, Chen W, Li J, Ding J, Mei X, Hu H. High glucose induces mouse mesangial cell overproliferation via inhibition of hydrogen sulfide synthesis in a TLR-4-dependent manner. Cell Physiol Biochem. 2017;41:1035–1043. - PubMed
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