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Clinical Trial
. 2020 Dec 23:14:5679-5687.
doi: 10.2147/DDDT.S276904. eCollection 2020.

Intravenous Iron Isomaltoside 1000 Reduces Postoperative Anemia in Patients Undergoing Elective Urologic Surgery and Those with Urosepsis

Hyeok Jun Goh  1 , Ki Soo Lee  1 , Tae Hyo Kim  1 , Kyu Nam Kim  2 , Hyun Jin Lim  2 , Kyu Shik Kim  3 , Won Jae Yang  4 , Jung Ki Jo  3
Affiliations
Clinical Trial

Intravenous Iron Isomaltoside 1000 Reduces Postoperative Anemia in Patients Undergoing Elective Urologic Surgery and Those with Urosepsis

Hyeok Jun Goh et al. Drug Des Devel Ther. .

Abstract

Purpose: Postoperative anemia is associated with increased morbidity and mortality in patients undergoing surgery. Anemia is also a common feature during sepsis. Therefore, here, we aimed to investigate the safety and efficacy of intravenous iron isomaltoside 1000 (Monofer®) in patients undergoing elective urologic surgery and in those with urosepsis.

Materials and methods: This multicenter study was conducted through the review of the medical records of patients with postoperative anemia undergoing elective urologic surgery or with urosepsis in a multicenter hospital. Patients received a single intravenous iron isomaltoside (IIM), and their hemoglobin (Hb) level was evaluated before and after administration of IIM. Safety data included adverse effects and hypersensitivity reactions. In addition, the patients were divided into three groups (200 mg, 400 mg, and 600 mg IIM) to compare Hb changes before and after the administration of IIM.

Results: The study analyzed 52 men and 30 women with a mean age of 67 years. There was a significant difference between pre-treatment Hb and post-treatment Hb according to the type of the surgery after administration (p=0.01) of IIM in patients with postoperative anemia, and the mean preoperative Hb before IIM administration was 8.5 g/dL and that after IIM administration was 9.9 g/dL (p=0.006) in patients with urosepsis. The mean preoperative Hb changed from 10 g/dL to 11 g/dL after administration (p<0.001) of IIM in the whole cohort. There were no side effects due to the administration of intravenous IIM.

Conclusion: A single perioperative intravenous injection of IIM 1000 significantly increased the Hb level in patients with anemia who underwent urologic elective surgery. Moreover, this treatment can be considered to have potential clinical benefits for anemia caused by sepsis.

Keywords: anemia; iron; iron isomaltoside 1000; urosepsis.

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Conflict of interest statement

The authors report no conflicts of interest for this work.

Figures

Figure 1
Figure 1
The change of hemoglobin level according to the type of surgery.
Figure 2
Figure 2
The differences of hemoglobin level for each surgery type. (A) Pre-treatment (B) Post-treatment.
Figure 3
Figure 3
The pre-treatment Hb level and post-treatment Hb level in patients with urosepsis.
See this image and copyright information in PMC

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