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Review
. 2020 Dec 14:8:616622.
doi: 10.3389/fped.2020.616622. eCollection 2020.

COVID-19 Pneumonia in Children: From Etiology to Management

Giuseppe Fabio Parisi  1 , Cristiana Indolfi  2 , Fabio Decimo  2 , Salvatore Leonardi  1 , Michele Miraglia Del Giudice  2
Affiliations
Review

COVID-19 Pneumonia in Children: From Etiology to Management

Giuseppe Fabio Parisi et al. Front Pediatr. .

Abstract

COVID-19 is less serious in children than in adults. However, respiratory management dominates the clinical picture of hospitalized COVID-19 even in children. In some case series, deterioration of the clinical picture wherein dyspnea, cyanosis, and the onset of acute respiratory distress syndrome (ARDS) emerged ~8-10 days after the onset of SARS-CoV-2 infection, which could rapidly progress to multiple organ failure and death. This review aimed to evaluate the characteristics of COVID-19 pneumonia in pediatric populations, beginning from its etiology and pathological mechanisms and closing with its clinical management.

Keywords: COVID-19; SARS-CoV2; children; pneumonia; treatment.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Graphic representation of the virus-host interaction and reasons why children are less affected. (1) Binding between SARS-CoV2 spike protein and ACE2 receptors; (2) transport of the ACE2 receptor/SARS-CoV 2 complex within the cell; (3) cleavage of the spike protein by the protease TMPRSS2; (4) release of viral RNA within the cell.
See this image and copyright information in PMC

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